Early effects of Roux-en-Y gastric bypass on peptides and hormones involved in the control of energy balance

Early effects of Roux-en-Y gastric bypass on peptides and hormones involved in the control of energy balance

Author Dal Molin Netto, Bárbara Autor UNIFESP Google Scholar
Earthman, Carrie P. Google Scholar
Bettini, Solange Cravo Google Scholar
Clemente, Ana Paula Grotti Autor UNIFESP Google Scholar
Masquio, Deborah Cristina Landi Autor UNIFESP Google Scholar
Farias, Gisele Google Scholar
Boritza, Katia Google Scholar
Silva, Larissa Gabrielle da Google Scholar
von der Heyde, Maria Emilia Google Scholar
Dâmaso, Ana Raimunda Autor UNIFESP Google Scholar
Abstract Introduction Body weight varies depending on the prevailing direction of environmental pressures

however, physiological factors also play a significant role in the control of body weight. The aim of the present study was to assess the impact of Roux-en-Y gastric bypass (RYGB) on hormones and peptides involved in the control of energy balance and their possible implications in appetite/satiety. Methods The sample included 39 individuals with extreme obesity (37 women and two men) who underwent RYGB. Anthropometric and biochemical markers were collected before surgery and 6 months after RYGB. Results The BMI decreased from 44.3 +/- 6.4 to 31.7 +/- 5.7 kg/m(2) (P<0.001) at the sixth month. Percentage of excess weight lost was 63.2 +/- 25.0%. Leptin and glucose levels decreased significantly 6 months after RYGB (P<0.001). Interestingly, a significant correlation was confirmed between the anorexigenic gut hormone peptide YY (PYY) and the central anorexigenic mediator alpha-melanocyte-stimulating hormone after 6 months of RYGB (r=0.35, P=0.004). In contrast, PYY concentrations were correlated negatively with BMI (r=-0.34, P=0.002). Conclusion In the present investigation, it was found that there is a relationship between a-melanocyte-stimulating hormone and PYY concentrations, and it supports the role of the PYY to POMC signal in appetite regulation after RYGB. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
Keywords Energy regulation
Gastric bypass
Gastrointestinal hormones
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP:2013/04136-4
CAPES: 2262/14-2
CAPES: 2566/2011
Date 2016
Published in European Journal Of Gastroenterology & Hepatology. Philadelphia, v. 28, n. 9, p. 1050-1055, 2016.
ISSN 0954-691X (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 1050-1055
Origin https://dx.doi.org/10.1097/MEG.0000000000000665
Access rights Closed access
Type Article
Web of Science ID WOS:000380805300012
URI https://repositorio.unifesp.br/handle/11600/51144

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