Effects of experimental sleep deprivation on anxiety-like behavior in animal research: Systematic review and meta-analysis

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dc.contributor.author Pires, Gabriel Natan [UNIFESP]
dc.contributor.author Bezerra, Andreia Gomes [UNIFESP]
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.contributor.author Andersen, Monica Levy [UNIFESP]
dc.date.accessioned 2019-07-22T15:46:51Z
dc.date.available 2019-07-22T15:46:51Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.1016/j.neubiorev.2016.06.028
dc.identifier.citation Neuroscience And Biobehavioral Reviews. Oxford, v. 68, p. 575-589, 2016.
dc.identifier.issn 0149-7634
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/51119
dc.description.abstract Increased acute anxiety is a commonly reported behavioral consequence of sleep deprivation in humans. However, rodent studies conducted so far produced inconsistent results, failing to reproduce the same sleep deprivation induced-anxiety observed in clinical experiments. While some presented anxiogenesis as result of sleep deprivation, others reported anxiolysis. In face of such inconsistencies, this article explores the effects of experimental sleep deprivation on anxiety-like behavior in animal research through a systematic review and a series of meta-analyses. A total of 50 of articles met our inclusion criteria, 30 on mice, 19 on rats and one on Zebrafish. Our review shows that sleep deprivation induces a decrease in anxiety-like behavior in preclinical models, which is opposite to results observed in human settings. These results were corroborated in stratified analyses according to species, sleep deprivation method and anxiety measurement technique. In conclusion, the use of animal models for the evaluation of the relationship between sleep deprivation lacks translational applicability and new experimental tools are needed to properly evaluate sleep deprivation-induced anxiogenesis in rodents. (C) 2016 Elsevier Ltd. All rights reserved. en
dc.description.sponsorship Associacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorship National Council of Technological and Scientific Development (CNPq)
dc.description.sponsorship Sao Paulo Research Foundation (FAPESP)
dc.format.extent 575-589
dc.language.iso eng
dc.publisher Pergamon-Elsevier Science Ltd
dc.rights Acesso restrito
dc.subject Animal behavior en
dc.subject Animal models en
dc.subject Anxiety en
dc.subject Elevated-plus-maze en
dc.subject Meta-analysis en
dc.subject Sleep en
dc.subject Sleep deprivation en
dc.subject Systematic review en
dc.title Effects of experimental sleep deprivation on anxiety-like behavior in animal research: Systematic review and meta-analysis en
dc.type Revisão
dc.description.affiliation Univ Fed Sao Paulo, Dept Psicobiol, Rua Napoleao de Barros,925 Vila Clementino, BR-04024002 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Psicobiol, Rua Napoleao de Barros,925 Vila Clementino, BR-04024002 Sao Paulo, Brazil
dc.identifier.doi 10.1016/j.neubiorev.2016.06.028
dc.description.source Web of Science
dc.identifier.wos WOS:000383293500039



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