Effects of experimental sleep deprivation on anxiety-like behavior in animal research: Systematic review and meta-analysis

Effects of experimental sleep deprivation on anxiety-like behavior in animal research: Systematic review and meta-analysis

Author Pires, Gabriel Natan Autor UNIFESP Google Scholar
Bezerra, Andreia Gomes Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Abstract Increased acute anxiety is a commonly reported behavioral consequence of sleep deprivation in humans. However, rodent studies conducted so far produced inconsistent results, failing to reproduce the same sleep deprivation induced-anxiety observed in clinical experiments. While some presented anxiogenesis as result of sleep deprivation, others reported anxiolysis. In face of such inconsistencies, this article explores the effects of experimental sleep deprivation on anxiety-like behavior in animal research through a systematic review and a series of meta-analyses. A total of 50 of articles met our inclusion criteria, 30 on mice, 19 on rats and one on Zebrafish. Our review shows that sleep deprivation induces a decrease in anxiety-like behavior in preclinical models, which is opposite to results observed in human settings. These results were corroborated in stratified analyses according to species, sleep deprivation method and anxiety measurement technique. In conclusion, the use of animal models for the evaluation of the relationship between sleep deprivation lacks translational applicability and new experimental tools are needed to properly evaluate sleep deprivation-induced anxiogenesis in rodents. (C) 2016 Elsevier Ltd. All rights reserved.
Keywords Animal behavior
Animal models
Anxiety
Elevated-plus-maze
Meta-analysis
Sleep
Sleep deprivation
Systematic review
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa (AFIP)
National Council of Technological and Scientific Development (CNPq)
Sao Paulo Research Foundation (FAPESP)
Date 2016
Published in Neuroscience And Biobehavioral Reviews. Oxford, v. 68, p. 575-589, 2016.
ISSN 0149-7634 (Sherpa/Romeo, impact factor)
Publisher Pergamon-Elsevier Science Ltd
Extent 575-589
Origin http://dx.doi.org/10.1016/j.neubiorev.2016.06.028
Access rights Closed access
Type Revisão
Web of Science ID WOS:000383293500039
URI http://repositorio.unifesp.br/handle/11600/51119

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