Effectiveness of an aquatic exercise program and low-level laser therapy on articular cartilage in an experimental model of osteoarthritis in rats

Effectiveness of an aquatic exercise program and low-level laser therapy on articular cartilage in an experimental model of osteoarthritis in rats

Author Milares, Luiz Paulo Autor UNIFESP Google Scholar
Autor UNIFESP Google Scholar
Siqueira, Amanda Autor UNIFESP Google Scholar
Claudino, Vitoria Autor UNIFESP Google Scholar
Domingos, Heloisa Autor UNIFESP Google Scholar
Almeida, Thais Autor UNIFESP Google Scholar
Tim, Carla Autor UNIFESP Google Scholar
Renno, Ana Claudia Autor UNIFESP Google Scholar
Abstract Objective: The aim of this study was to evaluate the effects of an aquatic exercise program and low-level laser therapy (LLLT) (associated or not) on degenerative modifications and inflammatory mediators on the articular cartilage using an experimental model of knee OA. Method: Forty male Wistar rats were divided into 4 groups: knee OA - without treatment (OA)

OA plus exercise program group (OAE)

OA plus LLLT (OAL)

OA plus exercise program associated with LLLT (OAEL). Trained rats performed a water-jumping program carrying a load equivalent to 50-80 % of their body mass strapped to their chest. The laser irradiation was used either as the only method or after the exercise training had been performed, at 2 points contact mode (medial and lateral side of the left joint). The treatments started 4 weeks after the surgery, 3 days/week for 8 weeks. Results: The results revealed that all treated groups (irradiated or not) exhibited a better pattern of tissue organization, with less fibrillation and irregularities along the articular surface and improved chondrocytes organization. Also, a lower cellular density and structural damage (OARSI score) and higher thickness values were observed in all treated groups. Additionally, OAE and OAEL showed a reduced expression in IL-1 and caspase-3 as compared with OA. Furthermore, a statistically lower MMP-13 expression was only observed in OAEL as compared with OA. Conclusion: These results suggest that aquatic exercise program and LLLT were effective in preventing cartilage degeneration. Also, physical exercise program presented anti-inflammatory effects in the knees in OA rats.
Keywords Aquatic exercise
articular cartilage
knee osteoarthritis
low-level laser therapy
rehabilitation
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
Grant number FAPESP: 2012-20145-0
Date 2016
Published in Connective Tissue Research. Philadelphia, v. 57, n. 5, p. 398-407, 2016.
ISSN 0300-8207 (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis Inc
Extent 398-407
Origin http://dx.doi.org/10.1080/03008207.2016.1193174
Access rights Closed access
Type Article
Web of Science ID WOS:000383444600007
URI http://repositorio.unifesp.br/handle/11600/51097

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