Mesenchymal stem cells and chronic renal artery stenosis

Mesenchymal stem cells and chronic renal artery stenosis

Autor Oliveira-Sales, Elizabeth B. Autor UNIFESP Google Scholar
Boim, Mirian A. Autor UNIFESP Google Scholar
Resumo Renal artery stenosis is the main cause of renovascular hypertension and results in ischemic nephropathy characterized by inflammation, oxidative stress, microvascular loss, and fibrosis with consequent functional failure. Considering the limited number of strategies that effectively control renovascular hypertension and restore renal function, we propose that cell therapy may be a promising option based on the regenerative and immunosuppressive properties of stem cells. This review addresses the effects of mesenchymal stem cells (MSC) in an experimental animal model of renovascular hypertension known as 2 kidney-1 clip (2K-1C). Significant benefits of MSC treatment have been observed on blood pressure and renal structure of the stenotic kidney. The mechanisms involved are discussed.
Assunto renal sympathetic nerve
renin-angiotensin system
renovascular hypertension
cell therapy
renal ischemiaExperimental Renovascular Disease
Endothelial Progenitor Cells
Angiotensin-Ii
Oxidative Stress
Nervous-System
Rat Model
Hypertension
Injury
Mechanisms
Senescence
Idioma Inglês
Financiador Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação Oswaldo Ramos (FOR)
Data 2016
Publicado em American Journal Of Physiology-Renal Physiology. Bethesda, v. 310, n. 1, p. F6-F9, 2016.
ISSN 1931-857X (Sherpa/Romeo, fator de impacto)
Editor Amer Physiological Soc
Extensão F6-F9
Fonte http://dx.doi.org/10.1152/ajprenal.00341.2015
Direito de acesso Acesso aberto Open Access
Tipo Revisão
Web of Science WOS:000366593500002
URI http://repositorio.unifesp.br/handle/11600/49697

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