Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. I. Systemic Disease

Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. I. Systemic Disease

Author Kohanim, Sahar Google Scholar
Palioura, Sotiria Google Scholar
Saeed, Hajirah N. Google Scholar
Akpek, Esen K. Google Scholar
Amescua, Guillermo Google Scholar
Basu, Sayan Google Scholar
Blomquist, Preston H. Google Scholar
Bouchard, Charles S. Google Scholar
Dart, John K. Google Scholar
Gai, Xiaowu Google Scholar
Gomes, Jose A. P. Autor UNIFESP Google Scholar
Gregory, Darren G. Google Scholar
Iyer, Geetha Google Scholar
Jacobs, Deborah S. Google Scholar
Johnson, Anthony J. Google Scholar
Kinoshita, Shigeru Google Scholar
Mantagos, Iason S. Google Scholar
Mehta, Jodhbir S. Google Scholar
Perez, Victor L. Google Scholar
Pflugfelder, Stephen C. Google Scholar
Sangwan, Virender S. Google Scholar
Sippel, Kimberly C. Google Scholar
Sotozono, Chie Google Scholar
Srinivasan, Bhaskar Google Scholar
Tan, Donald T. H. Google Scholar
Tandon, Radhika Google Scholar
Tseng, Scheffer C. G. Google Scholar
Ueta, Mayumi Google Scholar
Chodosh, James Google Scholar
Abstract The intent of this review is to comprehensively appraise the state of the art with regard to Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), with particular attention to the ocular surface complications and their management. SJS and TEN represent two ends of a spectrum of immune-mediated, dermatobullous disease, characterized in the acute phase by a febrile illness followed by skin and mucous membrane necrosis and detachment. The widespread keratinocyte death seen in SJS/TEN is rapid and irreversible, and even with early and aggressive intervention, morbidity is severe and mortality not uncommon. We have divided this review into two parts. Part I summarizes the epidemiology and immunopathogenesis of SJS/TEN and discusses systemic therapy and its possible benefits. We hope this review will help the ophthalmologist better understand the mechanisms of disease in SJS/TEN and enhance their care of patients with this complex and often debilitating disease. Part II (April 2016 issue) will focus on ophthalmic manifestations.
Keywords apoptosis
drug-induced disease
immune-mediated disease
keratinocyte death Stevens-Johnson Syndrome
toxic epidermal necrolysisAdverse Drug-Reactions
Colony-Stimulating Factor
Intravenous Immunoglobulin Therapy
Ocular Surface Complications
Dexamethasone Pulse Therapy
Severe Mucosal Involvement
Erythema Multiforme Major
Cytotoxic T-Cells
Language English
Sponsor Research to Prevent Blindness, NY, NY
Date 2016
Published in Ocular Surface. Amsterdam, v. 14, n. 1, p. 2-19, 2016.
ISSN 1542-0124 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 2-19
Access rights Closed access
Type Article
Web of Science ID WOS:000367241300002

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