Inhibition of bacterial and fungal pathogens by the orphaned drug auranofin

Inhibition of bacterial and fungal pathogens by the orphaned drug auranofin

Author Fuchs, Beth Burgwyn Google Scholar
RajaMuthiah, Rajmohan Google Scholar
Souza, Ana Carolina Remondi Autor UNIFESP Google Scholar
Eatemadpour, Soraya Google Scholar
Rossoni, Rodnei Dennis Google Scholar
Santos, Daniel Assis Google Scholar
Junqueira, Juliana C. Google Scholar
Rice, Louis B. Google Scholar
Mylonakis, Eleftherios Google Scholar
Abstract Background: We identified auranofin as an antimicrobial compound utilizing a high-throughput screen using a Caenorhabditis elegans-Staphylococcus aureus infection model. Results/methodology: Treatment of infected nematodes with auranofin resulted in a prolonged survival rate of 95%, reached with 0.78 mu g/ml. Further investigation of the antimicrobial activity of auranofin found inhibition against S. aureus, Enterococcus faecium and Enterococcus faecalis. Importantly, the fungal pathogens Cryptococcus neoformans was also effectively inhibited with an MIC at 0.5 mu g/ml. Auranofin appears to target the thioredoxin system. Conclusion: This work provides extensive additional data on the antibacterial effects of auranofin that includes both reference and clinical isolates and reports a novel inhibition of fungal pathogens by this compound.
Keywords Antimicrobial
Auranofin
Bucillus Subtilis
Candida Albicans
Cryptococcus Neoformans
Enterococcus Faecalis
Enterococcus Faecium
Staphylococcus AureusCandida-Albicans
Cryptococcus-Neoformans
Thioredoxin Reductase
Redox Homeostasis
Glutathione
Management
Viability
Mechanism
Selenium
Stress
Language English
Sponsor COBRE-Immune-based intervention against infectious diseases pilot grant
Brown University Dean's Emerging Areas of New Science award
NIH
Brown-Brazil Initiative
Date 2016
Published in Future Medicinal Chemistry. London, v. 8, n. 2, p. 117-132, 2016.
ISSN 1756-8919 (Sherpa/Romeo, impact factor)
Publisher Future sci ltd
Extent 117-132
Origin https://doi.org/10.4155/fmc.15.182
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000369950000004
URI http://repositorio.unifesp.br/handle/11600/49616

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