High-sensitivity c-reactive protein and cardiovascular disease across countries and ethnicities

High-sensitivity c-reactive protein and cardiovascular disease across countries and ethnicities

Author Helfenstein Fonseca, Francisco Antonio Autor UNIFESP Google Scholar
de Oliveira Izar, Maria Cristina Autor UNIFESP Google Scholar
Abstract Despite substantial differences in ethnicities, habits, cultures, the prevalence of traditional cardiovascular risk factors and affordable therapies, atherosclerosis remains the major cause of death in developing and developed countries. However, irrespective of these differences, inflammation is currently recognized as the common pathway for the major complications of atherosclerosis, stroke, and ischemic heart disease. A PubMed search was conducted for "high-sensitivity C-reactive protein'' (hs-CRP) in combination with the terms race, ethnicity, gender, prevalence, geographic, epidemiology, cardiovascular, obesity, diabetes, hypertension, cholesterol, smoking, ischemic heart disease, stroke, and mortality. This review includes the articles that pertained to the topic and additional articles identified from the reference lists of relevant publications. This review describes the marked differences in cardiovascular mortality across countries and ethnicities, which may be attributed to inequalities in the prevalence of the classic risk factors and the stage of cardiovascular epidemiological transition. However, hs-CRP appears to contribute to the prognostic information regarding cardiovascular risk and mortality even after multiple adjustments. Considering the perception of cardiovascular disease as an inflammatory disease, the more widespread use of hs-CRP appears to represent a valid tool to identify people at risk, independent of their ancestry or geographic region. In conclusion, this review reports that the complications associated with vulnerable atherosclerotic plaques are triggered by the major mechanisms of dyslipidemia and inflammation

whereas both mechanisms are influenced by classic risk factors, hs-CRP contributes additional information regarding cardiovascular events and mortality.
Keywords C-Reactive Protein
Ethnic Groups
Risk Factors
Cardiovascular DiseaseDensity-Lipoprotein Cholesterol
Evaluating Rosuvastatin Jupiter
Coronary-Heart-Disease
Apparently Healthy-Men
14 Randomized-Trials
Statin Therapy
Intervention Trial
Primary Prevention
Ldl Cholesterol
General-Population
Language English
Date 2016
Published in Clinics. Sao paulo, v. 71, n. 4, p. 235-242, 2016.
ISSN 1807-5932 (Sherpa/Romeo, impact factor)
Publisher Hospital clinicas, univ sao paulo
Extent 235-242
Origin http://dx.doi.org/10.6061/clinics/2016(04)11
Access rights Open access Open Access
Type Revisão
Web of Science ID WOS:000378142200011
URI http://repositorio.unifesp.br/handle/11600/49485

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