Self-perception of knowledge and adherence reflecting the effectiveness of antiretroviral therapy

Self-perception of knowledge and adherence reflecting the effectiveness of antiretroviral therapy

Author Dagli-Hernandez, Carolina Google Scholar
Lucchetta, Rosa Camila Google Scholar
de Nadai, Tales Rubens Google Scholar
Fernandez Galduroz, Jose Carlos Autor UNIFESP Google Scholar
Mastroianni, Patricia de Carvalho Google Scholar
Abstract Objectives: To evaluate which indirect method for assessing adherence best reflects highly active antiretroviral therapy (HAART) effectiveness and the factors related to adherence. Method: This descriptive, cross-sectional study was performed in 2012 at a reference center of the state of Sao Paulo. Self-report (simplified medication adherence questionnaire [SMAQ]) and drug refill parameters were compared to the viral load (clinical parameter of the effectiveness of pharmacotherapy [EP]) to evaluate the EP. The "Cuestionario para la Evaluacion de la Adhesion al Tratamiento Antiretroviral" (CEAT-VIH) was used to evaluate factors related to adherence and the EP and, complementarily, patient self-perception of adherence was compared to the clinical parameter of the EP. Results: Seventy-five patients were interviewed, 60 of whom were considered as adherent from the clinical parameter of the EP and ten were considered as adherent from all parameters. Patient self-perception about adherence was the instrument that best reflected the EP when compared to the standardized self-report questionnaire (SMAQ) and drug refill parameter. The level of education and the level of knowledge on HAART were positively correlated to the EP. Forgetfulness, alcohol use, and lack of knowledge about the medications were the factors most frequently reported as a cause of nonadherence. Conclusion: A new parameter of patient self-perception of adherence, which is a noninvasive, inexpensive instrument, could be applied and assessed as easily as self-report (SMAQ) during monthly drug refill, since it allows monitoring adherence through pharmaceutical assistance. Therefore, patient adherence to HAART could be evaluated using self-perception (CEAT-VIH) and the viral load test.
Keywords Health Literacy
Anti-Hiv Agents
Patient Compliance
Antiretroviral Therapy
Highly Active
Acquired Immunodeficiency SyndromeHiv-Infected Patients
Less-Than 95-Percent
Medication Adherence
Brazil
Care
Questionnaire
Suppression
Challenges
Literacy
Hiv/Aids
Language English
Sponsor Program of Support to Scientific Development of the School of Pharmaceutical Sciences at the Universidade Estadual Paulista - UNESP [2010/21-I]
FAPESP [2014/03468-6]
Grant number Program of Support to Scientific Development of the School of Pharmaceutical Sciences at the Universidade Estadual Paulista - UNESP: 2010/21-I
FAPESP: 2014/03468-6
Date 2016
Published in Patient Preference And Adherence. Albany, v. 10, p. 1787-1793, 2016.
ISSN 1177-889X (Sherpa/Romeo, impact factor)
Publisher Brazilian Soc Urol
Extent 1787-1793
Origin https://doi.org/10.2147/PPA.S112108
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000383153700006
URI http://repositorio.unifesp.br/handle/11600/49414

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