Autonomic and renal alterations in the offspring of sleep-restricted mothers during late pregnancy

Autonomic and renal alterations in the offspring of sleep-restricted mothers during late pregnancy

Author Raimundo, Joyce R. S. Autor UNIFESP Google Scholar
Bergamaschi, Cassia T.| Autor UNIFESP Google Scholar
Palma, Beatriz D. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Gomes, Guiomar N. Autor UNIFESP Google Scholar
Abstract OBJECTIVES: Considering that changes in the maternal environment may result in changes in progeny, the aim of this study was to investigate the influence of sleep restriction during the last week of pregnancy on renal function and autonomic responses in male descendants at an adult age. METHODS: After confirmation of pregnancy, female Wistar rats were randomly assigned to either a control or a sleep restriction group. The sleep-restricted rats were subjected to sleep restriction using the multiple platforms method for over 20 hours per day between the 14 th and 20 th day of pregnancy. After delivery, the litters were limited to 6 offspring that were designated as offspring from control and offspring from sleep-restricted mothers. Indirect measurements of systolic blood pressure (BPi), renal plasma flow, glomerular filtration rate, glomerular area and number of glomeruli per field were evaluated at three months of age. Direct measurements of cardiovascular function (heart rate and mean arterial pressure), cardiac sympathetic tone, cardiac parasympathetic tone, and baroreflex sensitivity were evaluated at four months of age. RESULTS: The sleep-restricted offspring presented increases in BPi, glomerular filtration rate and glomerular area compared with the control offspring. The sleep-restricted offspring also showed higher basal heart rate, increased mean arterial pressure, increased sympathetic cardiac tone, decreased parasympathetic cardiac tone and reduced baroreflex sensitivity. CONCLUSIONS: Our data suggest that reductions in sleep during the last week of pregnancy lead to alterations in cardiovascular autonomic regulation and renal morpho-functional changes in offspring, triggering increases in blood pressure.
Keywords Prenatal Exposure Delayed Effects
Hypertension
Kidney Disease
Sleep RestrictionBlood-Pressure
Angiotensin-Ii
Heart-Rate
Antenatal Betamethasone
Cardiovascular-Disease
Essential-Hypertension
Arterial-Pressure
Deprivation
Rats
Stress
Language English
Sponsor Fundacao de Amparo a Pesquisa [FAPESP-2013-23622-7]
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Grant number FAPESP: 2013-23622-7
Date 2016
Published in Clinics. Sao paulo, v. 71, n. 9, p. 521-527, 2016.
ISSN 1807-5932 (Sherpa/Romeo, impact factor)
Publisher Atha Comunicacao & Editora
Extent 521-527
Origin http://dx.doi.org/10.6061/clinics/2016(09)07
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000382872800007
SciELO ID S1807-59322016000900521 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/49411

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