Development of silver nanoparticles-based sensor for detection of quinolones by surface-enhanced raman spectroscopy: a case-study using levofloxacin

Development of silver nanoparticles-based sensor for detection of quinolones by surface-enhanced raman spectroscopy: a case-study using levofloxacin

Author Madalossi, Natiara V. Google Scholar
Mazali, Italo O. Google Scholar
Corbi, Fabiana C. A. Google Scholar
Sigoli, Fernando A. Google Scholar
Santos, Elias B. Autor UNIFESP Google Scholar
Abstract Numerous studies have shown that a variety of pharmaceuticals such as quinolones have been detected in the vicinity of municipal wastewater discharges and livestock agricultural facilities. Many of those works have been employed conventional analytical techniques and traditional methods of detection. However, in many cases these detection methodologies are time consuming and generate waste, which can be overcome using Surface-enhanced Raman spectroscopy (SERS) as analytical technique. In the present work, silver nanoparticles (AgNP) films were prepared on amine-modified glass slides with different number of depositions. The AgNP aggregates films were tested as SERS substrates using 4-aminobenzenethiol (4-ABT) as model Raman molecule. A trend between the 4-ABT SERS response and the number of AgNP deposition could be identified, which can be associated with the formation of AgNP aggregates. The aggregation effect could be quantified by calculating the enhancement factor (EF), which was on order of 10(6) for the film with five AgNP depositions. This optimized AgNP film was employed as SERS sensor of Levofloxacin in different concentrations, which was easily detected from 10(-4), 10(-5), and 10(-6) mol L-1 solution. Also, the SERS spectral profile are rich in information, which allowed to describe the chemical interaction between the Levofloxacin molecules and the AgNP sensor surface. This study provides an efficient method for detecting of Levofloxacin using AgNP SERS sensor, which can be extended for others quinolones.
Keywords Gold Nanoparticles
Scattering
4-Aminobenzenethiol
Aggregation
Language English
Date 2016
Published in International Conference On Nanotechnology Based Innovative Applications For The Environment. Milano, v. 47, p. 31-36, 2016.
ISSN 1974-9791 (Sherpa/Romeo, impact factor)
Publisher Wiley
Extent 31-36
Origin http://dx.ddoi.org/10.3303/CET1647006
Access rights Closed access
Type Conference paper
Web of Science ID WOS:000383875000006
URI http://repositorio.unifesp.br/handle/11600/49395

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