Polycystic ovary syndrome and mental disorders: a systematic review and exploratory meta-analysis

Polycystic ovary syndrome and mental disorders: a systematic review and exploratory meta-analysis

Author Blay, Sergio Luis Autor UNIFESP Google Scholar
Augusto Aguiar, Joao Vicente Google Scholar
Passos, Ives Cavalcante Google Scholar
Abstract Background: The association between depression, anxiety, and polycystic ovary syndrome (PCOS) is still unclear. Therefore, a systematic review and meta-analysis was conducted to assess the rates of comorbid psychiatric disorders among women with PCOS compared to women without it. Methods: PubMed/MEDLINE, Embase, PsycINFO, and Web of Science databases were searched from inception to November 27, 2015. Studies were eligible for inclusion if they were original reports in which the rates of mood (bipolar disorder, dysthymia, or major depressive disorder), obsessive-compulsive spectrum disorders, trauma- and stressor-related disorders, anxiety disorders or psychotic disorders, somatic symptom and related disorders, or eating disorders had been investigated among women with an established diagnosis of PCOS and compared with women without PCOS. Psychiatric diagnosis should have been established by means of a structured diagnostic interview or through a validated screening tool. Data were extracted and pooled using random effects models. Results: Six studies were included in the meta-analysis

of these, five reported the rates of anxiety and six provided data on the rates of depression. The rate of subjects with anxiety symptoms was higher in patients with PCOS compared to women without PCOS (odds ratio (OR) =2.76

95% confidence interval (CI) 1.26 to 6.02

Log OR = 1.013

P=0.011). The rate of subjects with depressive symptoms was higher in patients with PCOS compared to women without PCOS (OR = 3.51

95% CI 1.97 to 6.24

Log OR =1.255

P < 0.001). Conclusion: Anxiety and depression symptoms are more prevalent in patients with PCOS.
Keywords Polycystic Ovary Syndrome
Depression
Anxiety
Epidemiological Survey
Meta-Analysis
Systematic ReviewWomen
Depression
Anxiety
Risk
Axis
Heterogeneity
Pcos
Language English
Sponsor National Council for Scientific and Technological Development (CNPq
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) [305274/2014-7]
Grant number CNPq: 305274/2014-7
Date 2016
Published in Neuropsychiatric Disease And Treatment. Albany, v. 12, p. 2895-2903, 2016.
ISSN 1178-2021 (Sherpa/Romeo, impact factor)
Publisher Univ Federal Estado Rio De Janeiro, Programa Pos-Graduacao & Enfermagem
Extent 2895-2903
Origin https://doi.org/10.2147/NDT.S91700
Access rights Open access Open Access
Type Revisão
Web of Science ID WOS:000387167500001
URI http://repositorio.unifesp.br/handle/11600/49363

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