(-)-epicatechin in vitro ameliorates erythrocyte protein carbonyl content in hypertensive patients: comparison with l-ascorbic acid

(-)-epicatechin in vitro ameliorates erythrocyte protein carbonyl content in hypertensive patients: comparison with l-ascorbic acid

Autor Kumar, Navneet Google Scholar
Maurya, Pawan Kumar Autor UNIFESP Google Scholar
Kant, Ruchi Google Scholar
Rizvi, Syed Ibrahim Google Scholar
Resumo Context: Oxidative stress plays a key role in the patho-physiology of hypertension. (-)-Epicatechin has many important biological properties. Objective: The present study was undertaken to evaluate effect of (-)-epicatechin on protein carbonyl content in gender-based hypertensive patients and normal subjects. Methods: The study was carried out on 83 normal (male: 42

female: 41) and 62 hypertensive subjects (male: 32

female: 30). In vitro effect on (-)-epicatechin and L-ascorbic acid was estimated on protein carbonyl content. Results: Result showed a significant (p < 0.001) increase in protein carbonyl content in hypertensive patients but no gender-based difference was observed. (-)-epicatechin shows significant (p < 0.001) dose-dependent effect as compared to L-ascorbic acid, which is manifested as decrease in protein carbonyl content. Conclusion: We hypothesizes that a higher intake of (-)-epicatechin may provide protection against hypertension in males and females.
Assunto Carbonyl Group
Epicatechin
Erythrocyte
Hypertension
Oxidative StressAge-Related-Changes
Blood-Pressure
Oxidative Stress
Arterial-Hypertension
Elderly-Patients
Risk-Factors
Vitamin-C
Gender
Heterogeneity
Epicatechin
Idioma Inglês
Financiador coordination of Improvement of Higher Education Personnel (CAPES), National Counsel of Technological and Scientific Development (CNPq), Brazil
Data 2016
Publicado em Archives Of Physiology And Biochemistry. Abingdon, v. 122, n. 3, p. 155-160, 2016.
ISSN 1381-3455 (Sherpa/Romeo, fator de impacto)
Editor Univ Estado Mato Grosso
Extensão 155-160
Fonte https://doi.org/10.3109/13813455.2016.1159699
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000386832300007
URI http://repositorio.unifesp.br/handle/11600/49358

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