Quercetin-modulated erythrocyte membrane sodium-hydrogen exchanger during human aging: correlation with atpase's

Quercetin-modulated erythrocyte membrane sodium-hydrogen exchanger during human aging: correlation with atpase's

Autor Kumar, Prabhanshu Google Scholar
Chand, Subhash Google Scholar
Maurya, Pawan Kumar Autor UNIFESP Google Scholar
Resumo Content: Quercetin uptake by erythrocytes is rapid. The sodium-hydrogen exchanger (NHE) is a secondary active transporter, regulating intracellular pH, Na+ concentration and cell volume. Objective: The aim of present study was to investigate NHE as a function of human age and effect of quercetin on its activity. The NHE activity was correlated with erythrocytes ATPases. Materials and methods: We analyzed normal, healthy subjects of both sexes (20-82 years). NHE activity was estimated in terms of amiloride-sensitive H+-efflux from acid-loaded cells. Results: A significant age-dependent increase in NHE activity was observed during aging in humans. Concentration (10(-3) M to 10(-8) M)-dependent in vitro treatment with quercetin causes inhibition of NHE activity. The Na+/K+ -ATPase (r = 0.8882) and Ca2+-ATPase (r = 0.9540) activities positively correlated with it. Discussion and conclusion: The present data show an additional mechanism where dietary flavonoids may exerts beneficial effect during aging.
Assunto Aging
Ca2+-Atpase
Na+/H+ Exchanger
Na+/K+-Atpase
QuercetinNa+/H+ Exchanger
Enzyme-Activities
Acidic Ph
Human Age
Cells
Transport
Cancer
Glutathione
Homeostasis
Inhibition
Idioma Inglês
Financiador coordination of Improvement of Higher Education Personnel (CAPES), National Counsel of Technological and Scientific Development (CNPq), Brazil
Data 2016
Publicado em Archives Of Physiology And Biochemistry. Abingdon, v. 122, n. 3, p. 141-147, 2016.
ISSN 1381-3455 (Sherpa/Romeo, fator de impacto)
Editor Hindawi Ltd
Extensão 141-147
Fonte https://doi.org/10.3109/13813455.2016.1150299
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000386832300005
URI http://repositorio.unifesp.br/handle/11600/49357

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