Clinical management of localized bcg adverse events in children

Show simple item record

dc.contributor.author Moreira, Thais das Neves Fraga [UNIFESP]
dc.contributor.author de Moraes-Pinto, Maria Isabel [UNIFESP]
dc.contributor.author Costa-Carvalho, Beatriz Tavares [UNIFESP]
dc.contributor.author Grumach, Anete Sevciovic
dc.contributor.author Weckx, Lily Yin [UNIFESP]
dc.date.accessioned 2019-01-21T10:29:31Z
dc.date.available 2019-01-21T10:29:31Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.1590/S1678-9946201658084
dc.identifier.citation Revista Do Instituto De Medicina Tropical De Sao Paulo. Sao paulo, v. 58, p. UNSP 84, 2016.
dc.identifier.issn 0036-4665
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/49255
dc.description.abstract BCG adverse events (BCG-AE) are rare conditions with no well-established treatment. This study aims to describe clinical characteristics and outcome of localized BCG-AE. Children with BCG-AEs who were treated at the Reference Center for Special Immunobiologicals of the Federal University of Sao Paulo from 2009 to 2011 were included. Patients were followed monthly until 3 months after healing. One hundred and twenty-seven patients with localized BCG-AE were followed: 67 (52.7%) had suppurative lymphadenitis en
dc.description.abstract 30 (23.6%) injection-site abscess en
dc.description.abstract five (3.9%) had enlarged lymph node > 3 cm en
dc.description.abstract four (3.1%) had ulcer > 1 cm en
dc.description.abstract and one (0.8%) had a local bacterial infection. Five patients (3.9%) had more than one BCG-AE simultaneously. Fifteen patients (11.8%) had atypical manifestations: seven wart-like lesions en
dc.description.abstract five BCG reactivations en
dc.description.abstract two other dermatologic lesions and one with vasomotor phenomenon. Isoniazid was used in 96 patients with typical BCG-AE (85.7%) until lesion resolution which took place 3.1 months later (in median) en
dc.description.abstract the healing rate was 90.6%. Patients with atypical manifestations had an individual approach. Regarding the outcome, 105/112 patients with typical AE and 13/15 patients with atypical AE had resolution of BCG-AE. Localized BCG-AE caused by BCG Moreau RJ had positive outcome when treated with a short course of isoniazid. Atypical BCG-AE are not infrequent. en
dc.description.sponsorship Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Brazil [11/21754-8]
dc.format.extent UNSP 84
dc.language.iso eng
dc.publisher Ios Press
dc.relation.ispartof Revista Do Instituto De Medicina Tropical De Sao Paulo
dc.rights Acesso aberto
dc.subject Bcg Vaccine en
dc.subject Adverse Event en
dc.subject Therapeutics en
dc.subject Mycobacterium BovisSevere Combined Immunodeficiency en
dc.subject Calmette-Guerin Vaccine en
dc.subject Complications en
dc.subject Disease en
dc.subject Adenitis en
dc.subject Brazil en
dc.title Clinical management of localized bcg adverse events in children en
dc.type Artigo
dc.description.affiliation Reference Center for Special Immunobiologicals, Division of Pediatric Infectious Diseases, Federal University of São Paulo, São Paulo, SP, Brazil
dc.description.affiliation Department of Pediatrics, Federal University of São Paulo, São Paulo, SP, Brazil
dc.description.affiliation Outpatient Clinic of Recurrent Infections, Faculty of Medicine ABC, Santo André, SP, Brazil
dc.description.affiliationUnifesp Reference Center for Special Immunobiologicals, Division of Pediatric Infectious Diseases, Federal University of São Paulo, São Paulo, SP, Brazil
dc.description.affiliationUnifesp Department of Pediatrics, Federal University of São Paulo, São Paulo, SP, Brazil
dc.description.sponsorshipID FAPESP: 11/21754-8
dc.identifier.file S0036-46652016005000266.pdf
dc.identifier.scielo S0036-46652016005000266
dc.identifier.doi 10.1590/S1678-9946201658084
dc.description.source Web of Science
dc.identifier.wos WOS:000396241000034



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account