Behavioral effects of essential oil of Citrus aurantium L. inhalation in rats

Behavioral effects of essential oil of Citrus aurantium L. inhalation in rats

Alternative title Efeitos comportamentais em ratos após inalação do óleo essencial de Citrus aurantium L.
Author Leite, Mariana P. Autor UNIFESP Google Scholar
Fassin Junior, Jaime Autor UNIFESP Google Scholar
Baziloni, Eliane Maria de Freitas Autor UNIFESP Google Scholar
Almeida, Reinaldo Nobrega de Google Scholar
Mattei, Rita Autor UNIFESP Google Scholar
Leite, Jose Roberto Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal da Paraíba Laboratório de Tecnologia Farmacêutica
Abstract The orange essential oil (OEO) and its components obtained from Citrus aurantium L. (Rutaceae) has been attracting interest due to its sedative and relaxing actions. In the present study, rats previously exposed to OEO at the concentrations of 1.0%; 2.5% and 5.0%, w/w, by inhalation during 7 minutes in acrylic boxes were evaluated in two anxiety models: elevated plus maze (EPM) and open-field. The OEO at the concentration of 2.5% increased both the time of the animals in the open arms of the EPM and the time of active social interaction in the open-field being longer than that of the diazepam group (1.5 mg/kg i.p). In conclusion, the decrease in the level of emotionality of the animals observed in the two experimental models suggests a possible central action, which is in agreement with the phytochemical profile of the oil under study, since it showed the presence of limonene (96.24%) and mircene (2.24%), components with a well-known depressant activity on the central nervous system.

O óleo essencial de laranja (OEL) e seus constituintes obtidos da Citrus aurantium L. (Rutaceae) têm despertado interesse pela sua ação sedativa e relaxante. No presente estudo, ratos previamente expostos à inalação do OEL nas concentrações de 1,0%; 2,5% e 5,0%, p/v, durante 7 minutos em caixas de acrílico, foram avaliados em dois modelos de ansiedade: labirinto em cruz elevado (LCE) e campo aberto. O OEL na concentração de 2,5% aumentou tanto o tempo de permanência dos animais nos braços abertos do LCE, como o tempo de interação social ativa no campo aberto, tendo sido superior ao grupo padrão diazepam (1,5 mg/kg) ip. A diminuição do grau de emocionalidade dos animais observada nos dois modelos experimentais sugere uma possível ação central, o que está de acordo com o perfil fitoquímico do óleo em estudo o qual mostrou a presença de limoneno (96,24%) e mirceno (2,24%), constituintes com comprovada atividade depressora sobre o sistema nervoso central.
Keywords Essential oil
Citrus aurantium
Rutaceae
orange oil
anxiety
inhalation
plus-maze
Óleo essencial
Citrus aurantium
Rutaceae
óleo de laranja
ansiedade
inalação
labirinto em cruz elevado
Language English
Date 2008-12-01
Published in LEITE, Mariana P. et al . Behavioral effects of essential oil of Citrus aurantium L. inhalation in rats. Rev. bras. farmacogn., João Pessoa , v. 18, supl. p. 661-666, dez. 2008
ISSN 0102-695X (Sherpa/Romeo, impact factor)
Publisher Sociedade Brasileira de Farmacognosia
Extent 661-666
Origin http://dx.doi.org/10.1590/S0102-695X2008000500003
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000264576500002
SciELO ID S0102-695X2008000500003 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/4679

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