Lipopolysaccharides and peptidoglycans modulating the interaction of Au naparticles with cell membranes models at the air-water interface

Lipopolysaccharides and peptidoglycans modulating the interaction of Au naparticles with cell membranes models at the air-water interface

Author Silva, Rafael Leonardo Cruz Gomes da Autor UNIFESP Google Scholar
Silva, Heloiza Fernanda Oliveira da Google Scholar
Gasparotto, Luiz Henrique da Silva Google Scholar
Caseli, Luciano Autor UNIFESP Google Scholar
Abstract Understanding the interactions between nanoparticles and biological surfaces is of great importance for many areas of nanomedicine and calls for detailed studies at the molecular level using simplified models of cellular membranes. In this paper, water-dispersed polyvinylpyrrolidonestabilized gold nanoparticles (AuNPs) were incorporated in floating monolayers of selected lipids at the air-water interface as cell membrane models. Surface pressure-area isotherms showed the condensation of glycoside-free lipid monolayers, suggesting their adsorption on the nanoparticle surface through the hydrophilic head groups. On the other hand, monolayers containing glycoside derivatives expanded upon AuNPs incorporation, pointing that the supramolecular structure formed should facilitate the incorporation of these nanoparticles in cellular membranes. These findings can be therefore correlated with the possible toxicity, microbicide and antitumorigenic effects of these nanoparticles in lipidic surfaces of erythrocyte and microbial membranes.
Keywords Gold nanoparticles
Airwater interface
Cell membrane models
Monolayers
Language English
Sponsor FAPESP
CNPq
Grant number FAPESP: 2015/102530
FAPESP: 2015/095863
CNPq: 400896/20168
CNPq: 442087/20144
Date 2018
Published in Biophysical Chemistry. Amsterdam, v. 238, p. 22-29, 2018.
ISSN 0301-4622 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 22-29
Origin http://dx.doi.org/10.1016/j.bpc.2018.04.007
Access rights Closed access
Type Article
Web of Science ID WOS:000433644900004
URI http://repositorio.unifesp.br/handle/11600/45963

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