Structural characterization of multilamellar liposomes coencapsulating curcumin and vitamin D-3

Structural characterization of multilamellar liposomes coencapsulating curcumin and vitamin D-3

Author Chaves, Matheus Andrade Google Scholar
Oseliero Filho, Pedro Leonidas Google Scholar
Jange, Camila Garcia Google Scholar
Sinigaglia-Coimbra, Rita Autor UNIFESP Google Scholar
Oliveira, Cristiano Luis Pinto Google Scholar
Pinho, Samantha Cristina Google Scholar
Abstract This study aimed the production of multilamellar liposomes coencapsulating two hydrophobic bioactives, curcumin and vitamin D-3, which present antioxidant and nutraceutical properties. Liposomes were produced by proliposomes hydration and stabilized with a mixture of xanthan and guar gums. Proliposomes were produced by coating of micronized sucrose method. Physicochemical properties of the dispersions were evaluated over 42 days of refrigerated storage. Microstructural characterization were performed by differential scanning calorimetry (DSC), small-angle X-ray scattering (SAXS) and small deformation rheological analyses. Liposomes showed spherical and near-spherical shapes and presented hydrodynamic diameters in the 680-1580 nm range. Curcumin and cholecalciferol were loaded into the same vesicles, with preservation efficiencies ranging from 89.6 to 93.3% and from 88.3 to 91.3%, respectively, after 42 days of storage. SAXS data showed that the lipid bilayer of liposomes produced in the presence of curcumin, vitamin D-3, or a mixture of both, are very similar. Also, higher amounts of vitamin D-3 did not affect negatively the stability of phospholipid vesicles. Overall, it was demonstrated that the coencapsulation of curcumin and vitamin D-3 by liposomes is feasible and high contents of bioactives were retained throughout the storage time.
Keywords Microencapsulation
Phospholipid vesicles
Small-angle X-ray scattering
Language English
Sponsor FAPESP
CAPES (Coordination of Improvement of Staff Level Superior, BR)
CNPq (National Council for Scientific and Technological Development, BR)
Grant number FAPESP: 2015/03362-6, 2014/23376-9
Date 2018
Published in Colloids And Surfaces A-Physicochemical And Engineering Aspects. Amsterdam, v. 549, p. 112-121, 2018.
ISSN 0927-7757 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 112-121
Access rights Closed access
Type Article
Web of Science ID WOS:000432551500013

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