Understanding the Effects of Colostomy-induced Alterations on Cutaneous Immunity

Understanding the Effects of Colostomy-induced Alterations on Cutaneous Immunity

Autor Alegre Salles, Valdemir Jose Google Scholar
Saad, Sarhan Sydney Autor UNIFESP Google Scholar
Franco, Marcello Fabiano Autor UNIFESP Google Scholar
Matos, Delcio Autor UNIFESP Google Scholar
Instituição Univ Taubate
Universidade Federal de São Paulo (UNIFESP)
Resumo Objective. This study describes the immunological response in the dermal layer of the peri-colostomic region, and identifies and quantifies the cellular elements present. Methods. Forty-one patients with colostomies present for more than 8 weeks were included. Thirty-one patients were men (75.6%) and 10 were women (24.4%) with an average age of 49.9 years. Thirty-four patients (82.9%) were classified as surgical risk class I and 7 patients (17.1%) were classified as class II. The data were analyzed statistically using the Mann-Whitney, Kruskal-Wallis, and Dunn tests using 0.05 or 5%. Results. Analysis of the immuno-cellular response regarding the time of permanence of the colostomy showed a significant frequency of T lymphocytes (pan T-CD3) in all the time periods in a significantly superior number (P < 0.001) than the B lymphocytes (CD20) and the T lymphocytes-natural killer (CD57). T-helper cells (CD4) were present in larger numbers in the first three periods. Conclusion, The presence of a colostomy for more than 8 weeks promotes the development of a chronic inflammation and an immuno-cellular response in the dermal layer of the peri-colostomy region. However, its intensity did not demonstrate a statistically significant difference based on time of colostomy existence. The immuno-cellular response in the peri-colostomic dermal area is composed of a major number of T lymphocytes (pan T-CD3) and T lymphocytes-helper (CD4), and is more numerous between the 16th and 20th weeks, whereas, less cellular activity was noted between the 30th and 50th weeks.
Idioma Inglês
Data 2009-07-01
Publicado em Wounds-a Compendium Of Clinical Research And Practice. Malvern: H M P Communications, v. 21, n. 7, p. 172-176, 2009.
ISSN 1044-7946 (Sherpa/Romeo, fator de impacto)
Editor H M P Communications
Extensão 172-176
Fonte http://www.woundsresearch.com/content/understanding-effects-colostomy-induced-alterations-cutaneous-immunity
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000268128600003
URI http://repositorio.unifesp.br/11600/45753

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