Nephrotoxicity of low-osmolality contrast media

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dc.contributor.author Laranja, Sandra Maria Rodrigues [UNIFESP]
dc.contributor.author Ajzen, Horacio [UNIFESP]
dc.contributor.author Schor, Nestor [UNIFESP]
dc.date.accessioned 2018-06-18T11:35:32Z
dc.date.available 2018-06-18T11:35:32Z
dc.date.issued 1997-01-01
dc.identifier http://dx.doi.org/10.3109/08860229709026294
dc.identifier.citation Renal Failure. New York: Marcel Dekker Inc, v. 19, n. 2, p. 307-314, 1997.
dc.identifier.issn 0886-022X
dc.identifier.uri http://repositorio.unifesp.br/11600/45192
dc.description.abstract To evaluate renal function after the use of a low-osmolality radiological contrast medium (CM), we prospectively analyzed 39 patients submitted to the following examinations: arteriography (n = 32), phlebography (n = 3), computed tomography (n = 3), angioplasty (n = 1), and retrograde pyelography (n = 1). The patients were divided into three groups: group I, control, formed by renal donors (CT n = 11 and 11 exams); group 2, hypertensive patients (HYPT, n = 15 and 16 exams); and group 3, patients with diseases of multiple etiologies (MIX, n = 13 patients and 13 exams). Additionally, the patients were divided according to their renal function into: group 4, with a moderate deficit of renal function, creatinine clearance (CrCl) 25 to 60 mL/min (n = 15 patients and 15 exams); and group 5, with a mild deficit of renal function, CrCl greater than or equal to 60 mL/min (n = 14 patients and 14 exams). The CM utilized was ioxaglic acid (Hexabrix(R)) the incidence of acute renal failure (ARF) among the patients studied was 12.5% (5/40), and CrCl was the best parameter to monitor the alterations in renal function, which occurred in 35% of the patients, although the changes were mild, reversible, and did not need any therapeutic interventions, The triggering of ARF in these patients may have been due to multiple factors presented at time of CM examination. Thus, it is not possible to identify a single risk factor. However, it is probable that previous important impairment of renal function was the most expressive risk factor. en
dc.format.extent 307-314
dc.language.iso eng
dc.publisher Marcel Dekker Inc
dc.relation.ispartof Renal Failure
dc.rights Acesso restrito
dc.subject arteriography en
dc.subject acute renal failure en
dc.subject low osmolality, radiological contrast media en
dc.subject renal function en
dc.title Nephrotoxicity of low-osmolality contrast media en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation UNIV FED SAO PAULO,ESCOLA PAULISTA MED,DIV NEPHROL,BR-04023900 SAO PAULO,SP,BRAZIL
dc.description.affiliationUnifesp UNIV FED SAO PAULO,ESCOLA PAULISTA MED,DIV NEPHROL,BR-04023900 SAO PAULO,SP,BRAZIL
dc.identifier.doi 10.3109/08860229709026294
dc.description.source Web of Science
dc.identifier.wos WOS:A1997WQ40600021



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