Activation of HPA Axis and Remodeling of Body Chemical Composition in Response to an Intense and Exhaustive Exercise in C57BL/6 Mice

Activation of HPA Axis and Remodeling of Body Chemical Composition in Response to an Intense and Exhaustive Exercise in C57BL/6 Mice

Author Rosa, Eloi Francisco Autor UNIFESP Google Scholar
Alves, Gabriel Andrade Autor UNIFESP Google Scholar
Luz, Jacqueline Autor UNIFESP Google Scholar
Silva, Sylvia Maria Affonso da Autor UNIFESP Google Scholar
Suchecki, Deborah Autor UNIFESP Google Scholar
Pesquero, João Bosco Autor UNIFESP Google Scholar
Aboulafia, Jeannine Autor UNIFESP Google Scholar
Nouailhetas, Nouailhetas, Viviane Louise Andree Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Santo Amaro
Abstract Several deleterious effects may occur when intense and exhaustive exercise (IE) is not well-planned. This study aimed to investigate the effects of a short duration IE on body chemical composition and hypothalamic-pituitary-adrenal (HPA) axis. C57Bl/6 mice were distributed into four groups (10 mice per group): control (C-4D and C-10D), 4 days (E-4D), and 10 days of IE (E-10D). IE program consisted of a daily running session at 85 % of maximum speed until the animal reached exhaustion. Body weight as well as total body water, fat and protein content were determined from animal carcasses. HPA activation was assessed by plasma corticosterone levels measured by radioimmunoassay and the weight of both the adrenal glands and thymus were measured. Plasma corticosterone levels increased by 64 % in both the E-4D and E-10D groups. The weight of the adrenal glands augmented by 74 % and 45 %, at 4 and 10 days of IE, respectively, whereas thymus weight diminished by 15 % only in the E-10D group. The total carcass fat content decreased by 20 % only at 4 days IE, whereas protein content decreased by 20 % in both E-4D and E-10D groups. A relationship between corticosterone plasma levels and loss of body protein content in both E-4D and E-10D groups was observed (R-2=0.999). We concluded that IE may be related to HPA axis activation associated with remodeling of body chemical composition in C57BL/6 mice.
Keywords Intense exercise
HPA axis
Body composition adrenal glands
Thymus
Gastrocnemius muscle
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2014-01-01
Published in Physiological Research. Prague 4: Acad Sciences Czech Republic, Inst Physiology, v. 63, n. 5, p. 605-613, 2014.
ISSN 0862-8408 (Sherpa/Romeo, impact factor)
Publisher Acad Sciences Czech Republic, Inst Physiology
Extent 605-613
Origin http://www.biomed.cas.cz/physiolres/pdf/63/63_605.pdf
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000345590100011
URI http://repositorio.unifesp.br/11600/45103

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