Resting energy expenditure in peritoneal dialysis patients

Resting energy expenditure in peritoneal dialysis patients

Author Bazanelli, Ana Paula Autor UNIFESP Google Scholar
Kamimura, Maria Ayako Autor UNIFESP Google Scholar
Silva, Camila Barbosa da Google Scholar
Avesani, Carla Maria Autor UNIFESP Google Scholar
Lopes, Miriam Ghedini Garcia Autor UNIFESP Google Scholar
Manfredi, Silvia Regina Autor UNIFESP Google Scholar
Draibe, Sergio Antonio Autor UNIFESP Google Scholar
Cuppari, Lilian Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objectives: This study aimed to evaluate whether resting energy expenditure (REE) of patients undergoing peritoneal dialysis (PD) therapy differs from that of healthy individuals, as well as to investigate the factors associated with REE in this sample of patients.Design: Cross-sectional study.Setting. Dialysis Unit of the Nephrology Division, Federal University of Sao Paulo-Oswaldo Ramos Foundation, Brazil.Subjects and Methods: The study examined the REE of 37 patients (20 mates, age 44.5 +/- 13 years) undergoing PD therapy. Only patients older than 18 years, on PD for at least 3 months, without catabolic illness, and with normal thyroid function were included. Patients were pair matched for age and gender with 37 healthy individuals. REE was measured by indirect calorimetry. Body composition was assessed by dual-energy x-ray absorptiometry in the patients and by bioelectrical impedance in the healthy individuals.Results: The REE of PD patients was similar to that of pair-matched controls (1372 * 266 and 1453 252 kcal/day respectively, p = 0.13) even when adjusted for lean body mass and gender (p = 0.56). The REE of PD patients was positively correlated with lean body mass (r = 0.60, p < 0.01), fat mass (r = 0.43, p < 0.01), body mass index (r = 0.60, p < 0.01), serum glucose (r = 0.36, p < 0.05), and protein equivalent of nitrogen appearance (PNA; r = 0.42, p < 0.01). There were no correlations between REE and glucose absorption, dialysis-related parameters, C-reactive protein, and energy or protein intake by 3-day food diary. In the multiple linear regression analysis, using REE as the dependent variable, the final model showed that lean body mass and female gender were determinants of REE in PD patients (R-2 = 0.44). When separate analysis by gender was performed, REE correlated directly with body fat in female patients (r = 0.70, p < 0.01) but not in male patients (r = 0.29, p = 0.21). On the other hand, lean body mass was significantly correlated with REE in male patients (r = 0.78, p < 0.01) but not in female patients (r = 0.47, p = 0.06).Conclusions: This study showed that REE of PD patients did not differ from that of healthy individuals. The strong association between body fat and REE in female patients remains to be further investigated.
Keywords chronic kidney disease
resting energy expenditure
Language English
Date 2006-11-01
Published in Peritoneal Dialysis International. Toronto: Multimed Inc, v. 26, n. 6, p. 697-704, 2006.
ISSN 0896-8608 (Sherpa/Romeo, impact factor)
Publisher Multimed Inc
Extent 697-704
Access rights Closed access
Type Article
Web of Science ID WOS:000243213700015

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