Is persistent hypotension after transient cardiogenic shock associated with an inflammatory response?

Is persistent hypotension after transient cardiogenic shock associated with an inflammatory response?

Author Park, M. Google Scholar
A.t., Maciel Google Scholar
Noritomi, D.t. Google Scholar
Brunialti, Milena Karina Coló Autor UNIFESP Google Scholar
Salomão, Reinaldo Autor UNIFESP Google Scholar
Schettino, G.p.p. Google Scholar
Azevedo, Luciano Cesar Pontes Autor UNIFESP Google Scholar
Institution Hospital Sírio-Libanês Instituto de Ensino e Pesquisa Laboratório de Pesquisa em Medicina Intensiva e Anestesiologia
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract We evaluated the recovery of cardiovascular function after transient cardiogenic shock. Cardiac tamponade was performed for 1 h and post-shock data were collected in 5 domestic large white female pigs (43 ± 5 kg) for 6 h. The control group (N = 5) was observed for 6 h after 1 h of resting. During 1 h of cardiac tamponade, experimental animals evolved a low perfusion status with a higher lactate level (8.0 ± 2.2 vs 1.9 ± 0.9 mEq/L), lower standard base excess (-7.3 ± 3.3 vs 2.0 ± 0.9 mEq/L), lower urinary output (0.9 ± 0.9 vs 3.0 ± 1.4 mL·kg-1·h-1), lower mixed venous saturation, higher ileum partial pressure of CO2-end tidal CO2 (EtCO2) gap and a lower cardiac index than the control group. Throughout the 6-h recovery phase after cardiac tamponade, tamponade animals developed significant tachycardia with preserved cardiac index, resulting in a lower left ventricular stroke work, suggesting possible myocardial dysfunction. Vascular dysfunction was present with persistent systemic hypotension as well as persistent pulmonary hypertension. In contrast, oliguria, hyperlactatemia and metabolic acidosis were corrected by the 6th hour. The inflammatory characteristics were an elevated core temperature and increased plasma levels of interleukin-6 in the tamponade group compared to the control group. We conclude that cardiovascular recovery after a transient and severe low flow systemic state was incomplete. Vascular dysfunction persisted up to 6 h after release of tamponade. These inflammatory characteristics may also indicate that inflammatory activation is a possible pathway involved in the pathogenesis of cardiogenic shock.
Keywords Cardiogenic shock
Cardiac tamponade
Systemic inflammatory response syndrome
Swine
Myocardial dysfunction
Inflammation
Language English
Date 2008-08-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 41, n. 8, p. 648-656, 2008.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 648-656
Origin http://dx.doi.org/10.1590/S0100-879X2008000800002
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000259282600002
SciELO ID S0100-879X2008000800002 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/4502

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