Fructose-1,6-diphosphate: Potential protection in cyclosporine-induced renal impairment

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dc.contributor.author Cardoso, Lucio Ronaldo
dc.contributor.author Santos, Oscar Fernando Pavão dos [UNIFESP]
dc.contributor.author Boim, Mirian Aparecida [UNIFESP]
dc.contributor.author Barros, Elvino José Guardião
dc.contributor.author Ajzen, Horacio [UNIFESP]
dc.contributor.author Schor, Nestor [UNIFESP]
dc.date.accessioned 2018-06-18T11:15:17Z
dc.date.available 2018-06-18T11:15:17Z
dc.date.issued 1996-01-01
dc.identifier http://dx.doi.org/10.1159/000188808
dc.identifier.citation Nephron. Basel: Karger, v. 72, n. 1, p. 67-71, 1996.
dc.identifier.issn 0028-2766
dc.identifier.uri http://repositorio.unifesp.br/11600/45001
dc.description.abstract There is evidence that fructose-1,6-diphosphate (FDP) provides protection from hepatic and cardiac toxic-induced damage and ischemic renal insult. To determine ifFDP also protects against cyclosporine (CsA)-induced nephrotoxicity, two groups of adult male Wistar rats were studied for whole kidney clearance rates. After two initial control periods, group 1 received only CsA (CsA, n = 8). Group 2 received FDP 350 mg/kg, followed by CsA 50 mg/kg (FDP-CsA, n = 6). In both groups, after a 30-min equilibration period, two additional clearance rates were measured (Post1 and Post2). A significant reduction in clearance rates was observed after drug infusion in both groups (approximately 58 and 64% in CsA and FDP-CsA groups, respectively, p < 0.05) with a recovery to control values in the Post2 period in the FDP-CsA group. These data suggest a protective effect of FDP on CsA-induced renal impairment. en
dc.format.extent 67-71
dc.language.iso eng
dc.publisher Karger
dc.relation.ispartof Nephron
dc.rights Acesso restrito
dc.subject nephrotoxicity en
dc.subject fructose-1,6-diphosphate en
dc.subject cyclosporine en
dc.subject acute renal failure en
dc.subject glomeruli en
dc.title Fructose-1,6-diphosphate: Potential protection in cyclosporine-induced renal impairment en
dc.type Artigo
dc.rights.license http://www.karger.com/Services/RightsPermissions
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution FED UNIV RIO DE JANEIRO
dc.contributor.institution UNIV FED RIO GRANDE SUL
dc.description.affiliation ESCOLA PAULISTA MED,DIV NEPHROL,BR-04023062 SAO PAULO,BRAZIL
dc.description.affiliation FED UNIV RIO DE JANEIRO,DIV NEPHROL,BR-21945 RIO JANEIRO,BRAZIL
dc.description.affiliation UNIV FED RIO GRANDE SUL,DIV NEPHROL,PORTO ALEGRE,RS,BRAZIL
dc.description.affiliationUnifesp ESCOLA PAULISTA MED,DIV NEPHROL,BR-04023062 SAO PAULO,BRAZIL
dc.identifier.doi 10.1159/000188808
dc.description.source Web of Science
dc.identifier.wos WOS:A1996TN97900009



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