Author |
Cardoso, Lucio Ronaldo
![]() Santos, Oscar Fernando Pavão dos ![]() ![]() Boim, Mirian Aparecida ![]() ![]() Barros, Elvino José Guardião ![]() Ajzen, Horacio ![]() ![]() Schor, Nestor ![]() ![]() |
Institution | Universidade Federal de São Paulo (UNIFESP) FED UNIV RIO DE JANEIRO UNIV FED RIO GRANDE SUL |
Abstract | There is evidence that fructose-1,6-diphosphate (FDP) provides protection from hepatic and cardiac toxic-induced damage and ischemic renal insult. To determine ifFDP also protects against cyclosporine (CsA)-induced nephrotoxicity, two groups of adult male Wistar rats were studied for whole kidney clearance rates. After two initial control periods, group 1 received only CsA (CsA, n = 8). Group 2 received FDP 350 mg/kg, followed by CsA 50 mg/kg (FDP-CsA, n = 6). In both groups, after a 30-min equilibration period, two additional clearance rates were measured (Post1 and Post2). A significant reduction in clearance rates was observed after drug infusion in both groups (approximately 58 and 64% in CsA and FDP-CsA groups, respectively, p < 0.05) with a recovery to control values in the Post2 period in the FDP-CsA group. These data suggest a protective effect of FDP on CsA-induced renal impairment. |
Keywords |
nephrotoxicity
fructose-1,6-diphosphate cyclosporine acute renal failure glomeruli |
Language | English |
Date | 1996-01-01 |
Published in | Nephron. Basel: Karger, v. 72, n. 1, p. 67-71, 1996. |
ISSN | 0028-2766 (Sherpa/Romeo, impact factor) |
Publisher | Karger |
Extent | 67-71 |
Origin |
|
Access rights | Closed access |
Type | Article |
Web of Science ID | WOS:A1996TN97900009 |
URI | http://repositorio.unifesp.br/11600/45001 |
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