Adverse Drug Reaction as Cause of Hospital Admission of Elderly People: a Pilot Study

Adverse Drug Reaction as Cause of Hospital Admission of Elderly People: a Pilot Study

Author Varallo, Fabiana Rossi Google Scholar
Lima, Marcos Fernando Rosalen Google Scholar
Galduróz, José Carlos Fernandes Autor UNIFESP Google Scholar
Mastroianni, Patrícia de Carvalho Google Scholar
Institution Univ Estadual Paulista
Universidade Federal de São Paulo (UNIFESP)
Abstract The objective of this study was to estimate the prevalence of adverse drug reactions (ADR) related to hospital admission of elderly people, identifying the use of potentially inappropriate medication (PIM), the ADR and the risk factors associated with the hospitalization. A cross-sectional study was conducted in a private hospital of Sao Paulo State, Brazil. All patients aged >= 60 years, admitted in the general practice ward in May 2006 were interviewed about the drugs used and the symptoms/complaints that resulted in hospitalization. More than a half (54.5 %) of elderly hospitalizations were related with ADR. The therapeutic classes involved with ADR were: cardiovascular (37.7 %), central nervous (34.6 %) and respiratory (5.7 %). The ADR observed were disorders in circulatory (28.4 %), digestive (20.0 %) and respiratory (18.9 %) tracts. 27 elderly had made PIM and in 20 of them this was the cause of hospitalization. Polypharmacy was an ADR risk factor (p = 0.021). These data allows the healthcare professionals upgrade, qualifying them in pharmcovigilance.
Keywords Adverse drug reaction
Elderly people
Hospital admission
Use of drugs
Language English
Sponsor School of Medical Sciences at Faculdade de Ciencias Farmaceuticas da UNESP- PADC
Grant number School of Medical Sciences at Faculdade de Ciencias Farmaceuticas da UNESP- PADC: 2007/02-I
Date 2011-03-01
Published in Latin American Journal Of Pharmacy. La Plata: Colegio Farmaceuticos Provincia De Buenos Aires, v. 30, n. 2, p. 347-353, 2011.
ISSN 0326-2383 (Sherpa/Romeo, impact factor)
Publisher Colegio Farmaceuticos Provincia De Buenos Aires
Extent 347-353
Origin http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_1_19.pdf
Access rights Closed access
Type Article
Web of Science ID WOS:000291136700019
URI http://repositorio.unifesp.br/11600/44844

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