Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

Author Murray, Christopher J. L. Google Scholar
Vos, Theo Google Scholar
Lozano, Rafael Google Scholar
Naghavi, Mohsen Google Scholar
Flaxman, Abraham D. Google Scholar
Michaud, Catherine Google Scholar
Ezzati, Majid Google Scholar
Shibuya, Kenji Google Scholar
Salomon, Joshua A. Google Scholar
Abdalla, Safa Google Scholar
Aboyans, Victor Google Scholar
Abraham, Jerry Google Scholar
Ackerman, Ilana Google Scholar
Aggarwal, Rakesh Google Scholar
Ahn, Stephanie Y. Google Scholar
Ali, Mohammed K. Google Scholar
Alvarado, Miriam Google Scholar
Anderson, H. Ross Google Scholar
Anderson, Laurie M. Google Scholar
Andrews, Kathryn G. Google Scholar
Atkinson, Charles Google Scholar
Baddour, Larry M. Google Scholar
Bahalim, Adil N. Google Scholar
Barker-Collo, Suzanne Google Scholar
Barrero, Lope H. Google Scholar
Bartels, David H. Google Scholar
Basanez, Maria-Gloria Google Scholar
Baxter, Amanda Google Scholar
Bell, Michelle L. Google Scholar
Benjamin, Emelia J. Google Scholar
Bennett, Derrick Google Scholar
Bernabe, Eduardo Google Scholar
Bhalla, Kavi Google Scholar
Bhandari, Bishal Google Scholar
Bikbov, Boris Google Scholar
Bin Abdulhak, Aref Google Scholar
Birbeck, Gretchen Google Scholar
Black, James A. Google Scholar
Blencowe, Hannah Google Scholar
Blore, Jed D. Google Scholar
Blyth, Fiona Google Scholar
Bolliger, Ian Google Scholar
Bonaventure, Audrey Google Scholar
Boufous, Soufi Ane Google Scholar
Bourne, Rupert Google Scholar
Boussinesq, Michel Google Scholar
Braithwaite, Tasanee Google Scholar
Brayne, Carol Google Scholar
Bridgett, Lisa Google Scholar
Brooker, Simon Google Scholar
Brooks, Peter Google Scholar
Brugha, Traolach S. Google Scholar
Bryan-Hancock, Claire Google Scholar
Bucello, Chiara Google Scholar
Buchbinder, Rachelle Google Scholar
Buckle, Geoffrey Google Scholar
Budke, Christine M. Google Scholar
Burch, Michael Google Scholar
Burney, Peter Google Scholar
Burstein, Roy Google Scholar
Calabria, Bianca Google Scholar
Campbell, Benjamin Google Scholar
Canter, Charles E. Google Scholar
Carabin, Helene Google Scholar
Carapetis, Jonathan Google Scholar
Carmona, Loreto Google Scholar
Cella, Claudia Google Scholar
Charlson, Fiona Google Scholar
Chen, Honglei Google Scholar
Cheng, Andrew Tai-Ann Google Scholar
Chou, David Google Scholar
Chugh, Sumeet S. Google Scholar
Coffeng, Luc E. Google Scholar
Colan, Steven D. Google Scholar
Colquhoun, Samantha Google Scholar
Colson, K. Ellicott Google Scholar
Condon, John Google Scholar
Connor, Myles D. Google Scholar
Cooper, Leslie T. Google Scholar
Corriere, Matthew Google Scholar
Cortinovis, Monica Google Scholar
De Vaccaro, Karen Courville Google Scholar
Couser, William Google Scholar
Cowie, Benjamin C. Google Scholar
Criqui, Michael H. Google Scholar
Cross, Marita Google Scholar
Dabhadkar, Kaustubh C. Google Scholar
Dahiya, Manu Google Scholar
Dahodwala, Nabila Google Scholar
Damsere-Derry, James Google Scholar
Danaei, Goodarz Google Scholar
Davis, Adrian Google Scholar
De Leo, Diego Google Scholar
Degenhardt, Louisa Google Scholar
Dellavalle, Robert Google Scholar
Delossantos, Allyne Google Scholar
Denenberg, Julie Google Scholar
Derrett, Sarah Google Scholar
Des Jarlais, Don C. Google Scholar
Dharmaratne, Samath D. Google Scholar
Dherani, Mukesh Google Scholar
Diaz-Torne, Cesar Google Scholar
Dolk, Helen Google Scholar
Dorsey, E. Ray Google Scholar
Driscoll, Tim Google Scholar
Duber, Herbert Google Scholar
Ebel, Beth Google Scholar
Edmond, Karen Google Scholar
Elbaz, Alexis Google Scholar
Ali, Suad Eltahir Google Scholar
Erskine, Holly Google Scholar
Erwin, Patricia J. Google Scholar
Espindola, Patricia Google Scholar
Ewoigbokhan, Stalin E. Google Scholar
Farzadfar, Farshad Google Scholar
Feigin, Valery Google Scholar
Felson, David T. Google Scholar
Ferrari, Alize Google Scholar
Ferri, Cleusa P. Google Scholar
Fevre, Eric M. Google Scholar
Finucane, Mariel M. Google Scholar
Flaxman, Seth Google Scholar
Flood, Louise Google Scholar
Foreman, Kyle Google Scholar
Forouzanfar, Mohammad H. Google Scholar
Fowkes, Francis Gerry R. Google Scholar
Fransen, Marlene Google Scholar
Freeman, Michael K. Google Scholar
Gabbe, Belinda J. Google Scholar
Gabriel, Sherine E. Google Scholar
Gakidou, Emmanuela Google Scholar
Ganatra, Hammad A. Google Scholar
Garcia, Bianca Google Scholar
Gaspari, Flavio Google Scholar
Gillum, Richard F. Google Scholar
Gmel, Gerhard Google Scholar
Gonzalez-Medina, Diego Google Scholar
Gosselin, Richard Google Scholar
Grainger, Rebecca Google Scholar
Grant, Bridget Google Scholar
Groeger, Justina Google Scholar
Guillemin, Francis Google Scholar
Gunnell, David Google Scholar
Gupta, Ramyani Google Scholar
Haagsma, Juanita Google Scholar
Hagan, Holly Google Scholar
Halasa, Yara A. Google Scholar
Hall, Wayne Google Scholar
Haring, Diana Google Scholar
Maria Haro, Josep Google Scholar
Harrison, James E. Google Scholar
Havmoeller, Rasmus Google Scholar
Hay, Roderick J. Google Scholar
Higashi, Hideki Google Scholar
Hill, Catherine Google Scholar
Hoen, Bruno Google Scholar
Hoffman, Howard Google Scholar
Hotez, Peter J. Google Scholar
Hoy, Damian Google Scholar
Huang, John J. Google Scholar
Ibeanusi, Sydney E. Google Scholar
Jacobsen, Kathryn H. Google Scholar
James, Spencer L. Google Scholar
Jarvis, Deborah Google Scholar
Jasrasaria, Rashmi Google Scholar
Jayaraman, Sudha Google Scholar
Johns, Nicole Google Scholar
Jonas, Jost B. Google Scholar
Karthikeyan, Ganesan Google Scholar
Kassebaum, Nicholas Google Scholar
Kawakami, Norito Google Scholar
Keren, Andre Google Scholar
Khoo, Jon-Paul Google Scholar
King, Charles H. Google Scholar
Knowlton, Lisa Marie Google Scholar
Kobusingye, Olive Google Scholar
Koranteng, Adofo Google Scholar
Krishnamurthi, Rita Google Scholar
Laden, Francine Google Scholar
Lalloo, Ratilal Google Scholar
Laslett, Laura L. Google Scholar
Lathlean, Tim Google Scholar
Leasher, Janet L. Google Scholar
Lee, Yong Yi Google Scholar
Leigh, James Google Scholar
Levinson, Daphna Google Scholar
Lim, Stephen S. Google Scholar
Limb, Elizabeth Google Scholar
Lin, John Kent Google Scholar
Lipnick, Michael Google Scholar
Lipshultz, Steven E. Google Scholar
Liu, Wei Google Scholar
Loane, Maria Google Scholar
Ohno, Summer Lockett Google Scholar
Lyons, Ronan Google Scholar
Mabweijano, Jacqueline Google Scholar
MacIntyre, Michael F. Google Scholar
Malekzadeh, Reza Google Scholar
Mallinger, Leslie Google Scholar
Manivannan, Sivabalan Google Scholar
Marcenes, Wagner Google Scholar
March, Lyn Google Scholar
Margolis, David J. Google Scholar
Marks, Guy B. Google Scholar
Marks, Robin Google Scholar
Matsumori, Akira Google Scholar
Matzopoulos, Richard Google Scholar
Mayosi, Bongani M. Google Scholar
McAnulty, John H. Google Scholar
McDermott, Mary M. Google Scholar
McGill, Neil Google Scholar
McGrath, John Google Scholar
Elena Medina-Mora, Maria Google Scholar
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Mensah, George A. Google Scholar
Merriman, Tony R. Google Scholar
Meyer, Ana-Claire Google Scholar
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Mitchell, Philip B. Google Scholar
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Moffitt, Terrie E. Google Scholar
Mokdad, Ali A. Google Scholar
Monasta, Lorenzo Google Scholar
Montico, Marcella Google Scholar
Moradi-Lakeh, Maziar Google Scholar
Moran, Andrew Google Scholar
Morawska, Lidia Google Scholar
Mori, Rintaro Google Scholar
Murdoch, Michele E. Google Scholar
Mwaniki, Michael K. Google Scholar
Naidoo, Kovin Google Scholar
Nair, M. Nathan Google Scholar
Naldi, Luigi Google Scholar
Narayan, K. M. Venkat Google Scholar
Nelson, Paul K. Google Scholar
Nelson, Robert G. Google Scholar
Nevitt, Michael C. Google Scholar
Newton, Charles R. Google Scholar
Nolte, Sandra Google Scholar
Norman, Paul Google Scholar
Norman, Rosana Google Scholar
O'Donnell, Martin Google Scholar
O'Hanlon, Simon Google Scholar
Olives, Casey Google Scholar
Omer, Saad B. Google Scholar
Ortblad, Katrina Google Scholar
Osborne, Richard Google Scholar
Ozgediz, Doruk Google Scholar
Page, Andrew Google Scholar
Pahari, Bishnu Google Scholar
Pandian, Jeyaraj Durai Google Scholar
Panozo Rivero, Andrea Google Scholar
Patten, Scott B. Google Scholar
Pearce, Neil Google Scholar
Perez Padilla, Rogelio Google Scholar
Perez-Ruiz, Fernando Google Scholar
Perico, Norberto Google Scholar
Pesudovs, Konrad Google Scholar
Phillips, David Google Scholar
Phillips, Michael R. Google Scholar
Pierce, Kelsey Google Scholar
Pion, Sebastien Google Scholar
Polanczyk, Guilherme Vanoni Autor UNIFESP Google Scholar
Polinder, Suzanne Google Scholar
Pope, C. Arden Google Scholar
Popova, Svetlana Google Scholar
Porrini, Esteban Google Scholar
Pourmalek, Farshad Google Scholar
Prince, Martin Google Scholar
Pullan, Rachel L. Google Scholar
Ramaiah, Kapa D. Google Scholar
Ranganathan, Dharani Google Scholar
Razavi, Homie Google Scholar
Regan, Mathilda Google Scholar
Rehm, Juergen T. Google Scholar
Rein, David B. Google Scholar
Remuzzi, Guiseppe Google Scholar
Richardson, Kathryn Google Scholar
Rivara, Frederick P. Google Scholar
Roberts, Thomas Google Scholar
Robinson, Carolyn Google Scholar
Rodriguez De Leon, Felipe Google Scholar
Ronfani, Luca Google Scholar
Room, Robin Google Scholar
Rosenfeld, Lisa C. Google Scholar
Rushton, Lesley Google Scholar
Sacco, Ralph L. Google Scholar
Saha, Sukanta Google Scholar
Sampson, Uchechukwu Google Scholar
Sanchez-Riera, Lidia Google Scholar
Sanman, Ella Google Scholar
Schwebel, David C. Google Scholar
Scott, James Graham Google Scholar
Segui-Gomez, Maria Google Scholar
Shahraz, Saeid Google Scholar
Shepard, Donald S. Google Scholar
Shin, Hwashin Google Scholar
Shivakoti, Rupak Google Scholar
Singh, David Google Scholar
Singh, Gitanjali M. Google Scholar
Singh, Jasvinder A. Google Scholar
Singleton, Jessica Google Scholar
Sleet, David A. Google Scholar
Sliwa, Karen Google Scholar
Smith, Emma Google Scholar
Smith, Jennifer L. Google Scholar
Stapelberg, Nicolas J. C. Google Scholar
Steer, Andrew Google Scholar
Steiner, Timothy Google Scholar
Stolk, Wilma A. Google Scholar
Stovner, Lars Jacob Google Scholar
Sudfeld, Christopher Google Scholar
Syed, Sana Google Scholar
Tamburlini, Giorgio Google Scholar
Tavakkoli, Mohammad Google Scholar
Taylor, Hugh R. Google Scholar
Taylor, Jennifer A. Google Scholar
Taylor, William J. Google Scholar
Thomas, Bernadette Google Scholar
Thomson, W. Murray Google Scholar
Thurston, George D. Google Scholar
Tleyjeh, Imad M. Google Scholar
Tonelli, Marcello Google Scholar
Towbin, Jeff Rey A. Google Scholar
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Venketasubramanian, N. Google Scholar
Wang, Mengru Google Scholar
Wang, Wenzhi Google Scholar
Watt, Kerrianne Google Scholar
Weatherall, David J. Google Scholar
Weinstock, Martin A. Google Scholar
Weintraub, Robert Google Scholar
Weisskopf, Marc G. Google Scholar
Weissman, Myrna M. Google Scholar
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Whiteford, Harvey Google Scholar
Wiebe, Natasha Google Scholar
Wiersma, Steven T. Google Scholar
Wilkinson, James D. Google Scholar
Williams, Hywel C. Google Scholar
Williams, Sean R. M. Google Scholar
Witt, Emma Google Scholar
Wolfe, Frederick Google Scholar
Woolf, Anthony D. Google Scholar
Wulf, Sarah Google Scholar
Yeh, Pon-Hsiu Google Scholar
Zaidi, Anita K. M. Google Scholar
Zheng, Zhi-Jie Google Scholar
Zonies, David Google Scholar
Lopez, Alan D. Google Scholar
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Abstract Background Measuring disease and injury burden in populations requires a composite metric that captures both premature mortality and the prevalence and severity of ill-health. The 1990 Global Burden of Disease study proposed disability-adjusted life years (DALYs) to measure disease burden. No comprehensive update of disease burden worldwide incorporating a systematic reassessment of disease and injury-specific epidemiology has been done since the 1990 study. We aimed to calculate disease burden worldwide and for 21 regions for 1990, 2005, and 2010 with methods to enable meaningful comparisons over time.Methods We calculated DALYs as the sum of years of life lost (YLLs) and years lived with disability (YLDs). DALYs were calculated for 291 causes, 20 age groups, both sexes, and for 187 countries, and aggregated to regional and global estimates of disease burden for three points in time with strictly comparable definitions and methods. YLLs were calculated from age-sex-country-time-specific estimates of mortality by cause, with death by standardised lost life expectancy at each age. YLDs were calculated as prevalence of 1160 disabling sequelae, by age, sex, and cause, and weighted by new disability weights for each health state. Neither YLLs nor YLDs were age-weighted or discounted. Uncertainty around cause-specific DALYs was calculated incorporating uncertainty in levels of all-cause mortality, cause-specific mortality, prevalence, and disability weights.Findings Global DALYs remained stable from 1990 (2.503 billion) to 2010 (2.490 billion). Crude DALYs per 1000 decreased by 23% (472 per 1000 to 361 per 1000). An important shift has occurred in DALY composition with the contribution of deaths and disability among children (younger than 5 years of age) declining from 41% of global DALYs in 1990 to 25% in 2010. YLLs typically account for about half of disease burden in more developed regions (high-income Asia Pacific, western Europe, high-income North America, and Australasia), rising to over 80% of DALYs in sub-Saharan Africa. In 1990, 47% of DALYs worldwide were from communicable, maternal, neonatal, and nutritional disorders, 43% from non-communicable diseases, and 10% from injuries. By 2010, this had shifted to 35%, 54%, and 11%, respectively. Ischaemic heart disease was the leading cause of DALYs worldwide in 2010 (up from fourth rank in 1990, increasing by 29%), followed by lower respiratory infections (top rank in 1990; 44% decline in DALYs), stroke (fifth in 1990; 19% increase), diarrhoeal diseases (second in 1990; 51% decrease), and HIV/AIDS (33rd in 1990; 351% increase). Major depressive disorder increased from 15th to 11th rank (37% increase) and road injury from 12th to 10th rank (34% increase). Substantial heterogeneity exists in rankings of leading causes of disease burden among regions.Interpretation Global disease burden has continued to shift away from communicable to non-communicable diseases and from premature death to years lived with disability. In sub-Saharan Africa, however, many communicable, maternal, neonatal, and nutritional disorders remain the dominant causes of disease burden. The rising burden from mental and behavioural disorders, musculoskeletal disorders, and diabetes will impose new challenges on health systems. Regional heterogeneity highlights the importance of understanding local burden of disease and setting goals and targets for the post-2015 agenda taking such patterns into account. Because of improved definitions, methods, and data, these results for 1990 and 2010 supersede all previously published Global Burden of Disease results.
Language English
Sponsor Berlin Heart Honoraria
Lundbeck
Medtronic
Prana Biotechnology
Safework Australia
Assurance-Maladie (CNAMTS) InVS
Inserm
CHU de Nancy
CHU de Nice
Conseil Regional de Lorraine
Societe Francaise de Negma-Lerads
Pfizer
Pierre Fabre Medicaments
Sanofi-Afentis France
Spanish Health Ministry
Hospital de Cruces Rheumatology Association
Novartis
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Takeda
Savient
Ardea
Regeneron
Allergan
URL pharmaceuticals
36 companies
National Institutes of Arthritis, Musculoskeletal and Skin Diseases (NIAMS)
National Institutes of Aging (NIA)
National Cancer Institute (NCI)
Agency for Health Quality and Research Center for Education and Research on Therapeutics (CERTs)
Wellcome Trust
Department of Health London for the National Health Service Information Centre
University of Leicester
Australian National Health and Medical Research Council (NHMRC)
Monash University
Cabrini Health
BUPA Foundation
NIH
National Institute of Environmental Health Sciences
Africa Programme for Onchocerciasis Control (WHO/APOC)
Victorian Infectious Diseases Reference Laboratory, Melbourne, Australia
Parkinson Council
Australian NHMRC
US Department of Veterans Affairs
Health Research Council of New Zealand
University of Otago
National Institute for Stroke and Applied Neurosciences
AUT University
NHMRC
Swedish Research Council
Bill and Melinda Gates Foundation
Australian National Health and Medical Research Council
World Health Organization
World Mental Health Japan (WMH-J)
Japan Ministry of Health, Labour, and Welfare
Australian Government
National Health and Medical Research Council of Australia
Arthritis Foundation of Australia
Tasmanian Community Fund
Masonic Centenary Medical Research Foundation
Royal Hobart Hospital Research Foundation
University of Tasmania
Tehran University of Medical Sciences
South African Medical Research Council Burden of Disease Research Unit
University of Cape Town School of Public Health and Family Medicine
Brien Holden Vision Institute
National Drug and Alcohol Research Centre (UNSW, Australia)
Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases
Biostatistics, Epidemiologic and Bioinformatic Training in Environmental Health Training Grant
Foundation for Alcohol Research and Education
Victorian Department of Health
Burke Global Health Fellowship
Harold Amos Medical Faculty Development Award of the Robert Wood Johnson Foundation
Vanderbilt Clinical and Translational Scholars Award
Spanish Society of Rheumatology (Sociedad Espanola de Reumatologia)
European Center for Injury Prevention, Universidad de Navarra
Department of Health and Ageing
Commonwealth Government of Australia
Institute of Bone and Joint Research (IBJR)
University of Sydney (USYD)
Wellcome Trust UK
Medical Research Council UK
Anthony Cerami and Ann Dunne Research Trust
Grant number Wellcome Trust: 098045
Wellcome Trust: 085308
NIH: K23 AG034236
Swedish Research Council: 2011-1071
Japan Ministry of Health, Labour, and Welfare: H13-SHOGAI-023
Japan Ministry of Health, Labour, and Welfare: H14-TOKUBETSU-026
Japan Ministry of Health, Labour, and Welfare: H16-KOKORO-013
Biostatistics, Epidemiologic and Bioinformatic Training in Environmental Health Training Grant: ES015459
National Institute of Environmental Health Sciences: ES00260
Date 2012-12-15
Published in Lancet. New York: Elsevier Science Inc, v. 380, n. 9859, p. 2197-2223, 2012.
ISSN 0140-6736 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 2197-2223
Origin http://dx.doi.org/10.1016/S0140-6736(12)61689-4
Access rights Closed access
Type Article
Web of Science ID WOS:000312387000016
URI http://repositorio.unifesp.br/11600/44837

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