The renal osteodystrophy pattern in Brazil and Uruguay: An overview

The renal osteodystrophy pattern in Brazil and Uruguay: An overview

Author Araújo, Sônia Maria Holanda Almeida Google Scholar
Ambrosoni, Pablo Google Scholar
Lobão, Rosélia Ribeiro dos Santos Autor UNIFESP Google Scholar
Caorsi, Hena Google Scholar
Moyses, Rosa Maria Affonso Google Scholar
Barreto, Fellype de Carvalho Autor UNIFESP Google Scholar
Olaizola, Ines Google Scholar
Cruz, Elisa de Albuquerque Sampaio da Google Scholar
Petraglia, Alicia Google Scholar
Reis, Luciene Machado dos Google Scholar
Duarte, Maria Eugenia Google Scholar
Jorgetti, Vanda Google Scholar
Carvalho, Aluizio Barbosa de Autor UNIFESP Google Scholar
Institution Cent Univ Venezuela
Universidade Federal de São Paulo (UNIFESP)
Abstract Background. The prevalence of the types of renal osteodystrophy (ROD) has changed in the last two decades. This study evaluates the prevalence and determining factors of the types of ROD in two countries in South America.Methods. Symptomatic patients who underwent bone biopsies for diagnostic purposes (1985 through 2001) were included in the study. In Brazil, a total of 2340 patients were reviewed, 93.1% on hemodialysis (HD), and 6.9% on continuous ambulatory peritoneal dialysis (CAPD). In Uruguay, 167 patients on hemodialysis were included. Uncalcified bone samples were analyzed in order to diagnose the different types of ROD.Results. Comparing. the 1980s to the 1990s, the prevalence of Brazilian patients with hyperparathyroid bone disease (HP) increased from 32.3% to 44.0%, while Al overload decreased from 61.3% to 42.4%. A logistic regression analysis showed that the main factors associated with HP included female gender, age of less than 40 years, black patients, longer time on dialysis, and absence of Al overload. In Uruguay, HP also increased over time from 31.8% to 70.5% (P < 0.05), while Al overload decreased from 42% to 27% (P < 0.05).Conclusion. A better control of Al overload may lead to a change in histologic pattern, as evidenced by the increasing prevalence of HP.
Keywords secondary hyperparathyroidism
aluminum
dialysis
bone biopsy
Language English
Date 2003-06-01
Published in Kidney International. New York: Nature Publishing Group, v. 63, p. S54-S56, 2003.
ISSN 0085-2538 (Sherpa/Romeo, impact factor)
Publisher Nature Publishing Group
Extent S62-S65
Origin http://dx.doi.org/10.1046/j.1523-1755.63.s85.13.x
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000182994200013
URI http://repositorio.unifesp.br/11600/44807

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