Is there a role for pericytic cells in the vascular bed of infantile hemangioendothelioma of the liver?

Is there a role for pericytic cells in the vascular bed of infantile hemangioendothelioma of the liver?

Author Zerbini, Maria Cláudia Nogueira Google Scholar
Vianna, M. R. Google Scholar
Ribeiro, D. Google Scholar
Ayoub, AAR Google Scholar
Porta, Gilda Google Scholar
Sesso, Antonio Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Electron microscopic examination of an infantile hemangioendothelioma (IHE) type I of the liver, appearing in a five month old child, showed a high density of pericytes in the walls of the neoplastic vessels. These vessels, in part of the IHE patients, establish an important arteriovenous shunt leading to high output, congestive cardiac failure. It is unclear whether functions ascribed to pericytes, such as participation in microvascular contractility or as suppressors of endothelial cell proliferation are involved in two noteworthy aspects of the present case. The child exhibited no congestive heart failure and the multiple nodular lesions underwent spontaneous regression.
Keywords PERICYTES
HEMANGIOENDOTHELIOMA
INFANTILE HEMANGIOENDOTHELIOMA
ARTERIOVENOUS SHUNT
LIVER
CAPILLARY VESSEL
Language English
Date 1991-01-01
Published in Journal Of Submicroscopic Cytology And Pathology. Bologna: Editrice Compositori Bologna, v. 23, n. 1, p. 141-145, 1991.
ISSN 1122-9497 (Sherpa/Romeo, impact factor)
Publisher Editrice Compositori Bologna
Extent 141-145
Access rights Closed access
Type Article
Web of Science ID WOS:A1991EU88000014
URI http://repositorio.unifesp.br/11600/44709

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