Promoter methylation analysis of SIRT3, SMARCA5, HTERT and CDH1 genes in aging and Alzheimer's disease

Promoter methylation analysis of SIRT3, SMARCA5, HTERT and CDH1 genes in aging and Alzheimer's disease

Author Silva, Patricia Natalia Oliveira da Autor UNIFESP Google Scholar
Gigek, Carolina Oliveira Autor UNIFESP Google Scholar
Leal, Mariana Ferreira Autor UNIFESP Google Scholar
Bertolucci, Paulo Henrique Ferreira Autor UNIFESP Google Scholar
Labio, Roger Willian de Google Scholar
Payão, Spencer Luiz Marques Autor UNIFESP Google Scholar
Smith, Marilia de Arruda Cardoso Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
FAMEMA
Abstract Longevity related genes were investigated concerning promoter methylation. SIRT3, SMARCA5, HTERT and CDH1 promoters were analyzed in peripheral blood in relation to gender, age and Alzheimer's disease ( AD). Methylation Specifc PCR assay (MSP) was used. There were no significant differences in methylation frequencies of SIRT3, SMARCA5 and CDH1 among young, elderly and AD groups (p > 0.05), showing no association with aging or AD. On the other hand, HTERT methylation frequency was associated with the aging process, in that AD patients differed from elderly controls (p = 0.0086), probably due to telomere and immune dysfunctions involved in AD pathogenesis.
Keywords aging
Alzheimer's disease
CDH1
DNA methylation
epigenetics
HTERT
SIRT3
SMARCA5
Language English
Date 2008-01-01
Published in Journal Of Alzheimers Disease. Amsterdam: Ios Press, v. 13, n. 2, p. 173-176, 2008.
ISSN 1387-2877 (Sherpa/Romeo, impact factor)
Publisher Ios Press
Extent 173-176
Origin http://dx.doi.org/10.3233/JAD-2008-13207
Access rights Closed access
Type Article
Web of Science ID WOS:000254303500007
URI http://repositorio.unifesp.br/11600/44173

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account