c-erbB-2 oncoprotein in gastric carcinoma: correlation with clinical stage and prognosis

c-erbB-2 oncoprotein in gastric carcinoma: correlation with clinical stage and prognosis

Author Oshima, Celina Tizuko Fujiyama Autor UNIFESP Google Scholar
Lanzoni, Valeria Pereira Autor UNIFESP Google Scholar
Iriya, K. Google Scholar
Forones, Nora Manoukian Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract The aim of this study was to investigate the expression of the oncogene c-erbB-2 in gastric tumors. Immunohistochemical study of the expression of c-erbB-2 was performed in formalin-fixed, paraffin-embedded sections from 82 gastric adenocarcinomas using polyclonal antibody. c-erbB-2-positive immunostaining was observed in 37 (45%) tumors. Positive staining was detected in 63% of well differentiated, 46% of moderately differentiated and 80% of papillary adenocarcinomas. In poorly differentiated adenocarcinomas, positivity for c-erbB-2 was observed in 21%. According to the Lauren classification, a higher frequency of c-erbB-2 positive staining was observed in intestinal type tumors (70%). During the follow-up period 43% of the patients with c-erbB-2 oncoprotein-negative tumors and 45% of the patients with c-erbB-2 oncoprotein-positive tumors died. There was no significant association between c-erbB-2 staining and sex, age, clinical stage, tumor grade, histological type or survival rates. In conclusion, almost half of the gastric cancers were positive for c-erbB-2. Nonetheless, the expression of c-erbB-2 oncoprotein did not play a role in prognosis.
Keywords c-erbB-2
gastric cancer
Language English
Date 2001-10-01
Published in International Journal Of Biological Markers. Milan: Wichtig Editore, v. 16, n. 4, p. 250-254, 2001.
ISSN 0393-6155 (Sherpa/Romeo, impact factor)
Publisher Wichtig Editore
Extent 250-254
Access rights Closed access
Type Article
Web of Science ID WOS:000173069700005
URI http://repositorio.unifesp.br/11600/44022

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