Healthcare-associated infections among neonates in Brazil

Healthcare-associated infections among neonates in Brazil

Author Pessoa-Silva, Carmem Lucia Autor UNIFESP Google Scholar
Richtmann, R. Google Scholar
Calil, R. Google Scholar
Santos, RMR Google Scholar
Costa, MLM Google Scholar
Frota, ACC Google Scholar
Wey, Sergio Barsanti Autor UNIFESP Google Scholar
Institution Universidade Federal do Rio de Janeiro (UFRJ)
Hosp & Maternidade Santa Joana
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Abstract OBJECTIVE: To describe the epidemiology of healthcare-associated infections (HAIs) among neonates.DESIGN: Prospective surveillance of HAls was conducted during 2 years. Infections beginning within 48 hours of birth were defined as HAIs of maternal origin. Death occurring during an active episode of HAI was considered related to HAI.SETTING: Seven neonatal units located in three Brazilian cities.PATIENTS: All admitted neonates were included and observed until discharge.RESULTS: Twenty-two percent of 4,878 neonates had at least one HAI. The overall incidence density was 24.9 per 1,000 patient-days, and 28.1% of all HAIs were maternally acquired. HAI rates ranged from 12.3% in the group with a birth weight (BW) of more than 2,500 g to 51.9% in the group with a BW of 1,000 g or less. The main HAIs were bloodstream infection (BSI) and pneumonia. Coagulase-negative staphylococci, Enterobacter species, Staphylococcus aureus, and Klebsiella pneumoniae were the main pathogens. Forty percent of all deaths were related to HAI. Central venous catheter (CVC)-associated BSIs per 1,000 CVC-days ranged from 17.3 (BW, 1,501 to 2,500 g; device utilization [DU] 0.11) to 34.9 (BW, less than or equal to 1,000 g; DU, 34.92). Ventilator-associated pneumonia per 1,000 ventilator-days ranged from 7.0 (BW, less than or equal to 1,000 g; DU, 0.34) to 9.2 (BW, 1,001 to 1,500 g; DU, 0.14).CONCLUSIONS: The high proportion of HAls of maternal origin highlights perinatal care issues in Brazil and the need to improve the diagnosis of neonatal HAls. The very low BW group and device-associated infections should be priorities for prevention strategies in this population.
Language English
Date 2004-09-01
Published in Infection Control And Hospital Epidemiology. Thorofare: Slack Inc, v. 25, n. 9, p. 772-777, 2004.
ISSN 0899-823X (Sherpa/Romeo, impact factor)
Publisher Slack Inc
Extent 772-777
Access rights Closed access
Type Article
Web of Science ID WOS:000223880100013

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