Activity of Hypericum brasiliense and Hypericum cordatum on the central nervous system in rodents

Activity of Hypericum brasiliense and Hypericum cordatum on the central nervous system in rodents

Author Mendes, Fúlvio Rieli Autor UNIFESP Google Scholar
Mattei, Rita Autor UNIFESP Google Scholar
Carlini, Elisaldo Araujo Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Hydroalcoholic extracts from species Hypericum brasiliense Choisy (HB) and Hypericum cordatum N(Vell. Conc.) N. Robson (HC), were evaluated on the central nervous system (CNS) in some pharmacological tests. Signs of toxicity were observed for both species during the initial screening when high doses of up to 100 mg/kg (i.p.) and 1000 mg/kg (oral) were utilized. HC presented greater toxicity, with LD(50) of 269 mg/kg, as compared to HB (537 mg/kg). Alterations in sleeping time and in motor coordination were not observed both for HB and for HC. On the other hand, both species showed signs of general depressant action on the CNS, verified by decreased motor activity. Furthermore, animals treated with HB presented an increase in response time to thermal stimulus with doses of 50 mg/kg (i.p.) and 500 mg/kg (oral) suggesting possible analgesic action. Both HB and HC were tested in animal models to verify antidepressant action (forced swimming and hypothermy induced by apomorphine). In these tests, neither of the plants inhibited hypothermy, nor did they reduce immobility time in forced swimming. (C) 2002 Elsevier Science B.V. All rights reserved.
Keywords Hypericum brasiliense
Hypericum cordatum
analgesic activity
Language English
Date 2002-10-01
Published in Fitoterapia. Amsterdam: Elsevier Science Bv, v. 73, n. 6, p. 462-471, 2002.
ISSN 0367-326X (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 462-471
Access rights Closed access
Type Article
Web of Science ID WOS:000178855800003

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