The use of vancomycin with its therapeutic and adverse effects: a review

The use of vancomycin with its therapeutic and adverse effects: a review

Author Bruniera, F. R. Google Scholar
Ferreira, F. M. Google Scholar
Saviolli, L. R. M. Autor UNIFESP Google Scholar
Bacci, M. R. Google Scholar
Feder, D. Google Scholar
Luz Goncalves Pedreira, M. da Autor UNIFESP Google Scholar
Peterlini, M. A. Sorgini Autor UNIFESP Google Scholar
Azzalis, L. A. Autor UNIFESP Google Scholar
Junqueira, V. B. Campos Autor UNIFESP Google Scholar
Fonseca, F. L. A. Autor UNIFESP Google Scholar
Institution Fac Med ABC
Universidade Federal de São Paulo (UNIFESP)
Abstract OBJECTIVE: Vancomycin (VCM) is a tricyclic glycopeptide antibiotic produced by Streptococcus orientalis. Widely used in hospitals, it is indicated to fight severe infections caused by Gram-positive bacteria, especially with the advent of MRSA (methicillin-resistant Staphylococcus aureus), penicillin-resistant pneumococci among others. Furthermore, it is indicated for the treatment of patients allergic to penicillins and cephalosporins. Dose recommendations, dilution rates and types of infusion are controversial and also result in toxic effects. Aim of this paper was to perform a literature review showing the therapeutic and adverse effects of vancomycin.MATERIALS AND METHODS: This is a literature review of recent articles published on MEDLINE and SciELO databases in English, Portuguese and Spanish.RESULTS: The main adverse effects of vancomycin are: hypotension, phlebitis, nephrotoxicity, ototoxicity, hypersensitivity reactions, red man syndrome, neutropenia, chills, fever, interstitial nephritis.CONCLUSIONS: The use of vancomycin is still very common; however, inadequate doses and prolonged therapy pose a risk of increasing minimum inhibitory concentrations (MICs), resulting in subtherapeutic levels, treatment failures and toxicity. Therefore, further studies should be conducted to optimize the administration of vancomycin, monitoring treatments from the beginning in order to ensure a safe and effective use of the drug.
Keywords Vancomycin
Endothelial injury
Oxidative stress
Language English
Date 2015-01-01
Published in European Review For Medical And Pharmacological Sciences. Rome: Verduci Publisher, v. 19, n. 4, p. 694-700, 2015.
ISSN 1128-3602 (Sherpa/Romeo, impact factor)
Publisher Verduci Publisher
Extent 694-700
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000351491900027

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