Relationship between angiogenesis and grade of histologic differentiation in endometrial adenocarcinoma

Relationship between angiogenesis and grade of histologic differentiation in endometrial adenocarcinoma

Author Speck, Neila Maria de Góis Autor UNIFESP Google Scholar
Focchi, José Autor UNIFESP Google Scholar
Alves, A. C. Google Scholar
Ribalta, Julisa Chamorro Lascasas Autor UNIFESP Google Scholar
Osório, Cintia Aparecida Bueno Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Inst Brasileiro Controle Canc
Abstract The objective of the study was to quantity vessels and to relate them to the degree of histologic differentiation in endometrial adenocarcinoma. We studied 35 cases of which ten were G1, 13 G2 and 12 G3 adenocarcinonias. The control group consisted of 11 atrophic and 10 proliferative endometria. From each case two histologic sections were obtained: one for hematoxylin-eosin staining and the other for immunohistochemical study with anti-CD34. Vessel count was performed by morphometric study. Mean vessel count was 15.3 for G 1: 19 for G2 and 22.7 for G3 adenocarcinomas; in the control group it was 11.6 for atrophic and 13.2 for proliferative endometria. Slightly differentiated adenocarcinoma presented greater angiogenesis than normal and well-differentiated carcinoma. In contrast. moderately differentiated carcinoma showed greater angiogenicity as related to normal endometrium, but did not differ from other tumoral endometria.
Keywords angiogenesis
adenocarcinoma
endometrium
Language English
Date 2005-01-01
Published in European Journal Of Gynaecological Oncology. Montreal: I R O G Canada, Inc, v. 26, n. 6, p. 599-601, 2005.
ISSN 0392-2936 (Sherpa/Romeo, impact factor)
Publisher I R O G Canada, Inc
Extent 599-601
Origin http://www.irog.net/download/?magazine=99
Access rights Closed access
Type Article
Web of Science ID WOS:000234262000004
URI http://repositorio.unifesp.br/11600/43593

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