Aerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle function

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dc.contributor.author Brum, P. C.
dc.contributor.author Bacurau, A. V. N.
dc.contributor.author Medeiros, A. [UNIFESP]
dc.contributor.author Ferreira, J. C. B.
dc.contributor.author Vanzelli, A. S.
dc.contributor.author Negrao, C. E.
dc.date.accessioned 2018-06-15T16:24:03Z
dc.date.available 2018-06-15T16:24:03Z
dc.date.issued 2011-09-01
dc.identifier http://dx.doi.org/10.1590/S0100-879X2011007500075
dc.identifier.citation Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 44, n. 9, p. 827-835, 2011.
dc.identifier.issn 0100-879X
dc.identifier.uri http://repositorio.unifesp.br/11600/43136
dc.description.abstract Heart failure is a common endpoint for many forms of cardiovascular disease and a significant cause of morbidity and mortality. Chronic neurohumoral excitation (i.e., sympathetic hyperactivity) has been considered to be a hallmark of heart failure and is associated with a poor prognosis, cardiac dysfunction and remodeling, and skeletal myopathy. Aerobic exercise training is efficient in counteracting sympathetic hyperactivity and its toxic effects on cardiac and skeletal muscles. In this review, we describe the effects of aerobic exercise training on sympathetic hyperactivity, skeletal myopathy, as well as cardiac function and remodeling in human and animal heart failure. We also discuss the mechanisms underlying the effects of aerobic exercise training. en
dc.format.extent 827-835
dc.language.iso eng
dc.publisher Assoc Bras Divulg Cientifica
dc.relation.ispartof Brazilian Journal Of Medical And Biological Research
dc.rights Acesso aberto
dc.subject Heart failure en
dc.subject Exercise training en
dc.subject Sympathetic hyperactivity en
dc.subject Ventricular function en
dc.subject Cardiac remodeling en
dc.subject Skeletal myopathy en
dc.title Aerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle function en
dc.type Artigo
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Stanford Univ
dc.description.affiliation Univ Sao Paulo, Dept Biodinam Movimento Corpo Humano, Escola Educ Fis & Esporte, BR-05508900 Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Biociencias, Santos, SP, Brazil
dc.description.affiliation Stanford Univ, Dept Chem & Syst Biol, Palo Alto, CA 94304 USA
dc.description.affiliation Univ Sao Paulo, Fac Med, Inst Coracao, BR-05508900 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Biociencias, Santos, SP, Brazil
dc.identifier.file S0100-879X2011000900002.pdf
dc.identifier.scielo S0100-879X2011000900002
dc.description.source Web of Science
dc.identifier.wos WOS:000295721500002



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