PLASMA, KALLIKREIN CLEARANCE BY THE LIVER - A REVIEW

PLASMA, KALLIKREIN CLEARANCE BY THE LIVER - A REVIEW

Author Borges, Durval Rosa Autor UNIFESP Google Scholar
Kouyoumdjian, Maria Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract 1. The liver is the main organ clearing both plasma and tissue kallikreins from the circulation. Hepatocytes are responsible for the internalization of rat plasma kallikrein (RPK) and the clearance of plasma kallikrein by the liver is Ca2+-independent. The binding site of RPK to the liver cell is located on its heavy chain which is not exposed on prokallikrein. An S-type lectin accounts for the receptor-mediated endocytosis of RPK.2. These properties of the liver are affected by pathological situations, particularly the acute-phase response to inflammation, in which the kallikrein-kinin system plays a major role. The hepatic clearance of the alpha(2)-macroglobulin-plasma kallikrein complex is less efficient than the clearance of the free enzyme.
Keywords KALLIKREIN
LIVER
ENDOCYTOSIS
ALPHA(2)-MACROGLOBULIN
Language English
Date 1994-08-01
Published in Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 27, n. 8, p. 2033-2041, 1994.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 2033-2041
Access rights Closed access
Type Article
Web of Science ID WOS:A1994PC60600036
URI http://repositorio.unifesp.br/11600/43072

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