EFFECTS OF AGE AND ISOLATION ON THE EVOLUTION OF CATALEPSY DURING CHRONIC HALOPERIDOL TREATMENT

EFFECTS OF AGE AND ISOLATION ON THE EVOLUTION OF CATALEPSY DURING CHRONIC HALOPERIDOL TREATMENT

Author Frussa-Filho, Roberto Autor UNIFESP Google Scholar
Otoboni, JR Google Scholar
Uema, F. T. Google Scholar
Palermo-Neto, João Autor UNIFESP Google Scholar
Institution FDN MUNICIPAL ENSINO SUPER MARILIA
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Sixteen young (5 months) and 16 old (20-24 months) male Wistar rats, housed together or in individual cages were observed for cataleptic behavior 10, 20 and 30 days after the beginning of chronic haloperidol treatment (1.0 mg/kg, twice daily, for 30 days). Catalepsy was measured by the bar test. Age increased the duration of haloperidol-induced catalepsy of isolated and group-housed tats in the three observation sessions (old-isolated = 7.4 +/- 0.2; old-group housed = 7.5 +/- 0.1; young-isolated = 6.3 +/- 0.2; young-group housed = 6.8 +/- 0.2 In seconds in session 1, for example). Conversely, isolation did not modify the sensitivity to the cataleptic effect of haloperidol. Even more important, no differences in duration of haloperidol-induced catalepsy were observed among the three sessions for each group. The results indicate that under the experimental conditions employed the animals did not develop tolerance nor sensitization to haloperidol-induced catalepsy. In addition, neither age nor isolation modified the absence of effects of repeated haloperidol treatment on the catalepsy behavior of rats.
Keywords AGE
ISOLATION
CATALEPSY
HALOPERIDOL
Language English
Date 1992-01-01
Published in Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 25, n. 9, p. 925-928, 1992.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 925-928
Access rights Closed access
Type Article
Web of Science ID WOS:A1992JV49800009
URI http://repositorio.unifesp.br/11600/43028

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