EFFECT OF AGE ON ANTINOCICEPTIVE EFFECTS OF ELEVATED PLUS-MAZE EXPOSURE

EFFECT OF AGE ON ANTINOCICEPTIVE EFFECTS OF ELEVATED PLUS-MAZE EXPOSURE

Author Frussa-Filho, Roberto Autor UNIFESP Google Scholar
Otoboni, JR Google Scholar
Giannotti, A. D. Google Scholar
Amaral, ACS Google Scholar
Conceição, Isaltino Marcelo da Autor UNIFESP Google Scholar
Institution FDN MUNICIPAL ENSINO SUPER MARILIA
Universidade Federal de São Paulo (UNIFESP)
Abstract It has been suggested that anxiety may be a critical factor in certain forms of non-opioid environmental analgesia. Furthermore, age has been reported to increase the anxiety levels in rats as measured in the elevated plus-maze. In the present investigation 10 young (3 months), 10 middle-aged (14-16 months) and 10 old (28-30 months) male Wistar tats were tested by the tail withdrawal assay of nociception before (baseline), and at 0 (T1) and 10 (T2) min after a 5-min exposure to the elevated plus-maze apparatus. Only old rats presented an increase in tail withdrawal latencies after elevated plus-maze exposure, even though this effect was statistically significant only immediately after exposure to the apparatus (baseline = 2.5 +/- 0.3 s; T1 = 3.8 +/- 0.3 s; T2 = 3.3 +/- 0.4 s). The results indicate that exposure to the elevated plus-maze induces a rapidly reversed and age-dependent antinociception in rats. They are also consistent with the proposed greater sensitivity of old rats to anxiogenic effects of the plus-maze.
Keywords ELEVATED PLUS-MAZE
NOCICEPTION
AGE
RAT
Language English
Date 1992-01-01
Published in Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 25, n. 8, p. 827-829, 1992.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 827-829
Access rights Closed access
Type Article
Web of Science ID WOS:A1992JM99700010
URI http://repositorio.unifesp.br/11600/43026

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