EFFECT OF THE NEONATAL STEROID-HORMONE TREATMENT OF RATS ON ADULT HORMONE LEVELS AND THE REACTIVITY OF SEMINAL-VESICLES TO PARASYMPATHOMIMETIC DRUGS

EFFECT OF THE NEONATAL STEROID-HORMONE TREATMENT OF RATS ON ADULT HORMONE LEVELS AND THE REACTIVITY OF SEMINAL-VESICLES TO PARASYMPATHOMIMETIC DRUGS

Author Barros, C. M. Google Scholar
Picarelli, Z. P. Google Scholar
Hayashi, Hisakazu Autor UNIFESP Google Scholar
Abreu, L. C. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract 1. Seminal vesicle reactivity to cholinergic agents, plasma testosterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH) concentrations and seminal vesicle testosterone concentrations were determined in adult male rats treated during the first 6 h of life with 1.0 ml peanut oil (oil-treated), 1.0 mg testosterone propionate (TP-treated) or 1.2 mg 19-nor-testosterone homofarnesate (19-NT-treated).2. At 90-100 days of age, the neonatally treated animals presented atrophied accessory genital organs and increased (TP-treated, N = 10) or unchanged (19-NT-treated, N = 11) pD2 values for acetylcholine (vehicle: 5.18 +/- 0.06, N = 10; TP-treated: 5.26 +/- 0.06, N = 10; 19-NT-treated: 5.14 +/- 0.09, N = 11), and acetyl-beta-methylcholine (vehicle: 5.19 +/- 0.07; TP-treated: 5.43 +/- 0.06; 19-NT-treated: 5.25 +/- 0.07). The relative intrinsic activity, alpha, of acetyl-beta-methylcholine increased after both hormonal treatments (vehicle: 0.85 +/- 0.03; TP-treated: 0.95 +/- 0.02; 19-NT-treated: 0.92 +/- 0.03).3. No variation in mean adult plasma testosterone concentration was observed after neonatal treatment with either TP of 19-NT (vehicle: 752.93 +/- 273.66, N = 8; TP-treated: 459.05 +/- 88.32, N = 8; 19-NT-treated: 836.86 +/- 113.08, N = 7). However, testosterone content of seminal vesicles of adult rats was decreased in the animals treated with TP (N = 5) and 19-NT (N = 6) compared to controls.4. These results indicate a specific effect of neonatal hormone treatment on androgen metabolism which is demonstrable in the adult.
Keywords SEMINAL VESICLES
NEONATAL TREATMENT
SEX HORMONES
TESTOSTERONE
19-NOR-TESTOSTERONE
ACETYLCHOLINE
ACETYL-BETA-METHYLCHOLINE
Language English
Date 1992-01-01
Published in Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 25, n. 2, p. 193-200, 1992.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 193-200
Access rights Closed access
Type Article
Web of Science ID WOS:A1992HK88400014
URI http://repositorio.unifesp.br/11600/43016

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