EVALUATION OF MEMORY AND ANXIETY IN RATS OBSERVED IN THE ELEVATED PLUS-MAZE - EFFECTS OF AGE AND ISOLATION

EVALUATION OF MEMORY AND ANXIETY IN RATS OBSERVED IN THE ELEVATED PLUS-MAZE - EFFECTS OF AGE AND ISOLATION

Autor Frussa-Filho, Roberto Autor UNIFESP Google Scholar
OTOBONI, JR Google Scholar
Uema, F. T. Google Scholar
Sarocha, L. C. Google Scholar
Instituição FDN MUNICIPAL ENSINO SUPER MARILIA
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo Twenty young (5 months) and 20 old (20-24 months) male Wistar rats, isolated or group housed, were tested in the elevated plus-maze to evaluate memory and anxiety. Memory was quantified by transfer latency (the time it took for the rat to move from the open arm to the enclosed arm) and anxiety by percent entries into the open arms. Isolation decreased the transfer latency of old (session 1 = 119.33 +/- 0.44 s; session 3 = 49.67 +/- 12.12 s) and young (session 1 = 111.20 +/- 8.80 s; session 3 = 55.90 +/- 13.60 s) rats, but did not modify percent entries into the open arms (old-isolated = 5.56 +/- 5.56; old-group housed = 10.18 +/- 7.05; young-isolated = 35.16 +/- 8.98; young-group housed = 33.21 +/- 8.11). Conversely, aging decreased percent entries into the open arms but did not affect the transfer latency of isolated or group-housed animals. The results indicate that the plus-maze test, unlike other methods for memory evaluation, does not discriminate between young and old rats. They also suggest that age increases anxiety and that isolation increases memory levels, but that there is no interaction between age and isolation with regard to their effect on memory and anxiety in rats.
Assunto AGE
ISOLATION
MEMORY
ANXIETY
ELEVATED PLUS-MAZE
Idioma Inglês
Data 1991-01-01
Publicado em Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 24, n. 7, p. 725-728, 1991.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Editor Assoc Bras Divulg Cientifica
Extensão 725-728
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1991GG90300009
URI http://repositorio.unifesp.br/11600/43008

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