Efeitos em curto prazo da aplicação de aloxana para indução de diabetes em ratos Wistar

Efeitos em curto prazo da aplicação de aloxana para indução de diabetes em ratos Wistar

Alternative title Effects in short-term of alloxan application to diabetes induction in Wistar rats
Author Leme, Jose Alexandre Curiacos de Almeida Google Scholar
Castellar, Alexandre Google Scholar
Remedio, Rafael Neodini Google Scholar
Barbosa, Rodrigo Avelaira Google Scholar
Moura, Leandro Pereira de Google Scholar
Dalia, Rodrigo Augusto Google Scholar
Gomes, Ricardo Jose Autor UNIFESP Google Scholar
Caetano, Flavio Henrique Google Scholar
Mello, Maria Alice Rostom de Google Scholar
Luciano, Eliete Google Scholar
Institution Univ Estadual Paulista
Universidade Federal de São Paulo (UNIFESP)
Abstract The present study aimed to verify action of alloxan in metabolic and immune parameters after 24 and 192 hours of the injection in Wistar rats. Thus, eight rats were fasted and received monohidrated alloxan Sigma (32 mg/kg body weight) via endovenous. Glycemia and trglyceridemia analyzes were performed before and 192 hours after alloxan application. After 24 hours, alloxan application increased water intake and decreased body mass, food intake and leucocytes counting. 192 hours after alloxan application, there was a recuperation in food intake and leucocytes counting. On the other hand, in this period there was an increase of glycemia and water intake and reduction of body mass. These results indicate that some of diabetic signs caused by alloxan occur in short-term after drug administration.
Keywords Alloxan
Diabetes
Metabolism
Immune System
Language Portuguese
Date 2010-05-01
Published in Bioscience Journal. Uberlandia: Univ Federal Uberlandia, v. 26, n. 3, p. 442-447, 2010.
ISSN 1516-3725 (Sherpa/Romeo, impact factor)
Publisher Univ Federal Uberlandia
Extent 442-447
Origin http://www.seer.ufu.br/index.php/biosciencejournal/article/view/7094/4858
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000282056200015
URI http://repositorio.unifesp.br/11600/42839

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