The role of cyclooxygenase-2 on endurance exercise training in female LDL-receptor knockout ovarieetomized mice

The role of cyclooxygenase-2 on endurance exercise training in female LDL-receptor knockout ovarieetomized mice

Author Oliveira, Flavia de Autor UNIFESP Google Scholar
Maifrino, Laura Beatriz Mesiano Autor UNIFESP Google Scholar
Jesus, Gustavo Protasio Pacheco de Autor UNIFESP Google Scholar
Carvalho, Juliana Goncalves Autor UNIFESP Google Scholar
Marchon, Claudia Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Sao Judas Tadeu
Inst Dante Pazzanese Cardiol
Abstract Estrogen deprivation in postmenopausal women increases cardiovascular risk. Cardiovascular risk as a result of atherosclerosis is able to induce an inflammatory disease as far as cyclooxygenase-2 (COX-2) expression. The purpose of the study was to investigate the role of COX-2 on exercise training in female mice low-density lipoprotein receptor knockout (LDL-KO) with or without ovariectomy. A total of 15 female C57BL/6 mice and 15 female LDE-KO mice were distributed into 6 groups: sedentary control, sedentary control ovariectomized, trained control ovariectomized, LDL-KO sedentary, LDL-KO sedentary ovariectomized and LDL-KO trained ovariectomized. The ascending part of the aorta was stained with H&E and COX-2 expression was assessed by immunohistochemistry. Results revealed that ovariectomy as well as exercise training were not able to induce histopathological changes in mouse aorta for all groups investigated. LDL-KO mice demonstrated plaque containing cholesterol clefts, foamy histiocytes and mild inflammatory process for all groups indistinctly. Ovariectomy induced a strong immunoexpression in atherosclerosis lesion of EDE-KO mice. Nevertheless, a down-regulation of COX-2 expression was detected in LDL-KO trained ovariectomized when compared to LDE-KO sedentary. Our results are consistent with the notion that exercise training is able to modulate COX-2 expression in LDL-KO mice as a result of COX-2 down-regulation.
Keywords atherosclerosis
Ciclooxygenase-2
exercise
menopause
Language English
Date 2013-09-01
Published in Anais Da Academia Brasileira De Ciencias. Rio Janeiro: Acad Brasileira De Ciencias, v. 85, n. 3, p. 1157-1164, 2013.
ISSN 0001-3765 (Sherpa/Romeo, impact factor)
Publisher Acad Brasileira De Ciencias
Extent 1157-1164
Origin http://dx.doi.org/10.1590/S0001-37652013005000046
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000324948400031
SciELO ID S0001-37652013005000046 (statistics in SciELO)
URI http://repositorio.unifesp.br/11600/42529

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