Long-term effects of maternal deprivation on the corticosterone response to stress in rats

Long-term effects of maternal deprivation on the corticosterone response to stress in rats

Author Suchecki, Deborah Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Twenty-four hours of maternal deprivation result in activation of the infant rat's adrenocortical axis. In the present study we examined the long-term effects of maternal deprivation on the corticosterone (Cort) response to stress. Pups were maternally deprived (Dep) on postnatal day (PND) 11 and tested immediately (PND 12) or returned to their mothers and tested at later ages. Testing consisted of a time course of the Cort response to a saline injection (5, 15, 30, and 60 min). At PND 12, the response of Dep pups was higher than that of nondeprived (non-Dep) pups. No group differences were observed at PND 16 and 22. On PND 30, Dep rats showed lower Cort levels than non-Dep pups at 0, 5, and 30 min after saline. At PND 60, non-Dep females showed higher Cort levels than males at 5, 15, and 30 min. This gender difference for Dep pups was observed only at 5 min. Male and female Dep animals presented lower Cort levels than non-Dep counterparts at 60 and 30 min after saline, respectively. These findings indicate that maternal deprivation effects on Cort secretion are long lasting. Dep rats showed a smaller adrenal response to stress at PND 30, whereas as adults the stress response was similar but the turnoff was different.
Keywords glucocorticoids
stress-hyporesponsive period
adult rats
Language English
Date 1997-10-01
Published in American Journal Of Physiology-regulatory Integrative And Comparative Physiology. Bethesda: Amer Physiological Soc, v. 273, n. 4, p. R1332-R1338, 1997.
ISSN 0363-6119 (Sherpa/Romeo, impact factor)
Publisher Amer Physiological Soc
Extent R1332-R1338
Origin http://ajpregu.physiology.org/content/273/4/R1332
Access rights Open access Open Access
Type Article
Web of Science ID WOS:A1997YA44700016
URI http://repositorio.unifesp.br/11600/42351

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