MicroRNAs in cancer treatment and prognosis

MicroRNAs in cancer treatment and prognosis

Author Schoof, Claudia Regina Gasque Autor UNIFESP Google Scholar
Botelho, Eder Leite da Silva Autor UNIFESP Google Scholar
Izzotti, Alberto Google Scholar
Vasques, Luciana dos Reis Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Univ Genoa
Abstract Disturbances in microRNA expression by epigenetic alterations and mutations may promote not only tumorigenesis but also tumor aggressiveness, invasion, metastasis, and resistance to chemotherapy and radiotherapy. Several studies have profiled microRNA expression in normal and tumorigenic tissues, demonstrating a unique microRNA signature, which can be used as a marker for cancer diagnosis and prognosis. This review discusses the importance of microRNAs as regulatory biomolecules involved in cancer, focusing on microRNAs related to cancer invasion, metastasis, epigenetic alterations, chemoresistance, and radioresistance. The identification of both differentially expressed microRNAs in tumors and their target genes provides new tools for gene therapy; the re-expression of microRNAs silenced by cancer development or the silencing of oncogenic microRNAs can be effective in the blockade of cancer-related cell proliferation.
Keywords MicroRNA
epigenetic modifications
metastasis
chemotherapy
radiotherapy
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Italian Association for Cancer Research (AIRC)
Grant number Italian Association for Cancer Research (AIRC): 8909
Date 2012-01-01
Published in American Journal Of Cancer Research. Madison: E-century Publishing Corp, v. 2, n. 4, p. 414-U136, 2012.
ISSN 2156-6976 (Sherpa/Romeo, impact factor)
Publisher E-century Publishing Corp
Extent 414-U136
Origin http://www.ajcr.us/ajcr0000120A.html
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000208854800005
URI http://repositorio.unifesp.br/11600/42251

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