Effects of aroeira (Schinus terebinthifoliu Raddi) oil on cutaneous wound healing in rats

Effects of aroeira (Schinus terebinthifoliu Raddi) oil on cutaneous wound healing in rats

Author Estevão, Lígia Reis Moura Google Scholar
Mendonca, Fábio de Souza Google Scholar
Evencio, Liriane Baratella Autor UNIFESP Google Scholar
Simões, Ricardo Santos Autor UNIFESP Google Scholar
Barros, Maria Edna Gomes de Google Scholar
Arantes, Rosa Maria Esteves Google Scholar
Rachid, Milene Alvarenga Google Scholar
Evencio Neto, Joaquim Autor UNIFESP Google Scholar
Institution UFRPE
Universidade Federal de Pernambuco (UFPE)
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Minas Gerais (UFMG)
Abstract PURPOSE: To evaluate the effects of aroeira (Schinus terebinthifolius) ointment on skin wound healing in rats.METHODS: Adult male rats (n=20) were divided into four groups of five animals each, as follows: G4, G7, G14 and G21, which corresponds to 4th, 7th, 14th and 21th days postoperatively. Each animal were made two incisions on the skin, including the subcutaneous tissue, in the right and left sides of thoracic region, separated by a distance of two inches. The right lesion was treated with base ointment (vaseline, lanolin); the left one was treated with base ointment containing 5% of aroeira oil. At the end of each experimental period the lesions were evaluated for the contraction degree. Then held the collection of fragments that were fixed in 10% formalin and processed for paraffin embedding. In the histological sections (5 mu m) was evaluated the morphology and quantified the collagen and blood vessels. The data obtained were submitted to ANOVA test complemented by Tukey-Kramer test (p<0.05).RESULTS: The contraction of the lesions was higher in wounds treated with aroeira oil than in controls at 7th and 14th days (p<0.01), whereas in the 21st day all lesions were already completely healed. The morphology showed granulation tissue more developed, with fibroblasts more bulky and collagen fibers more arranged in the experimental group at 4th, 7th and 14th days. The morphometry showed a significant increase in the quantification of collagen fibers in the experimental group at 7th and 14th days (p<0.05).CONCLUSION: The aroeira oil accelerates the healing process of wounds as a macroscopic, morphological and morphometrical analysis.
Keywords Wound Healing
Angiogenesis Inducing Agents
Language English
Sponsor FACEPE (Pernambuco Research Foundation)
Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2013-03-01
Published in Acta Cirurgica Brasileira. Sao Paulo: Acta Cirurgica Brasileira, v. 28, n. 3, p. 202-209, 2013.
ISSN 0102-8650 (Sherpa/Romeo, impact factor)
Publisher Acta Cirurgica Brasileira
Extent 202-209
Origin http://dx.doi.org/10.1590/S0102-86502013000300008
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000316126000008
SciELO ID S0102-86502013000300008 (statistics in SciELO)
URI http://repositorio.unifesp.br/11600/41985

Show full item record


File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)




My Account