Morphological changes in distant muscle fibers following thermal injury in Wistar rats

Morphological changes in distant muscle fibers following thermal injury in Wistar rats

Alternative title Alterações morfológicas das fibras musculares de um músculo distante da lesão térmica em ratos Wistar
Author Oliveira, Flavia de Autor UNIFESP Google Scholar
Bevilacqua, Luci Rezende Google Scholar
Anaruma, Carlos Alberto Google Scholar
Boldrini, Silvia de Campos Google Scholar
Liberti, Edson Aparecido Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Purpose: Thermal injury causes catabolic processes as the body attempts to repair the damaged area. This study evaluated the effects of a scald injury on the morphology of muscle fibers belonging to a muscle distant from the lesion. Methods: Thirty Wistar rats were divided into control (C) and scalded (S) groups. Group S was scalded over 45% of the body surface, standardized by body weight. Rats in both groups were euthanized at four, seven and 14 days following the injury. The middle portions of the medial gastrocnemius muscles were sectioned, stained with hematoxylin and eosin and Picrosirius, and submitted to histological analysis. Results: Control group sections exhibited equidistantly distributed polygonal muscle fibers with peripheral nuclei, characteristic of normal muscle. The injured group sections did not consistently show these characteristics; many fibers in these sections exhibited a rounded contour, variable stain intensities, and greater interfiber distances. A substantially increased amount of connective tissue was also observed on the injured group sections. Conclusion: This experimental model found a morphological change in muscle distant from the site of thermal injury covering 45% of the body surface.
Keywords Morphology
Muscle Fibers, Skeletal
Connective Tissue
Language English
Date 2010-11-01
Published in Acta Cirurgica Brasileira. Sao Paulo: Acta Cirurgica Brasileira, v. 25, n. 6, p. 525-528, 2010.
ISSN 0102-8650 (Sherpa/Romeo, impact factor)
Publisher Acta Cirurgica Brasileira
Extent 525-528
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000284779000012
SciELO ID S0102-86502010000600012 (statistics in SciELO)

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