Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction

Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction

Author Saraiva, Roberto Magalhães Autor UNIFESP Google Scholar
Kanashiro-Takeuchi, Rosimeire Miyuki Autor UNIFESP Google Scholar
Antonio, Ednei Luiz Autor UNIFESP Google Scholar
Campos Filho, Orlando Autor UNIFESP Google Scholar
Tucci, Paulo José Ferreira Autor UNIFESP Google Scholar
Moisés, Valdir Ambrósio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The severity of left ventricular (LV) dysfunction in rats with myocardial infarction (MI) varies widely. Because homogeneity in baseline parameters is essential for experimental investigations, a study was conducted to establish whether Doppler echocardiography (DE) could accurately identify animals with high LV end-diastolic pressure as a marker of LV dysfunction soon after MI. Direct measurements of LV end-diastolic pressure were made and DE was performed simultaneously 1 week after surgically induced MI (N = 16) or sham-operation (N = 17) in female Wistar rats (200 to 250 g). The ratio of peak early (E) to late (A) diastolic LV filling velocities and the ratio of E velocity to peak early (Em) diastolic myocardial velocity were the best predictors of high LV end-diastolic pressure (>12 mmHg) soon after MI. Cut-off values of 1.77 for the E/A ratio (P = 0.001) identified rats with elevated LV end-diastolic pressure with 90% sensitivity and 80% specificity. Cut-off values of 20.4 for the E/Em ratio (P = 0.0001) identified rats with elevated LV end-diastolic pressure with 81.8% sensitivity and 80% specificity. Moreover, E/A and E/Em ratios were the only echocardiographic parameters independently associated with LV end-diastolic pressure in multiple linear regression analysis. Therefore, DE identifies rats with high LV end-diastolic pressure soon after MI. These findings have implications for using serial DE in animal selection and in the assessment of their response to experimental therapies.
Keywords Heart failure
Myocardial infarction
Echocardiography
Hemodynamics
Language English
Date 2007-11-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 11, p. 1557-1565, 2007.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 1557-1565
Origin http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100016
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000250175400016
SciELO ID S0100-879X2007001100016 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/3992

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