Soybean isoflavones attenuate the expression of genes related to endometrial cancer risk

Soybean isoflavones attenuate the expression of genes related to endometrial cancer risk

Author Ferraz Carbonel, A. A. Autor UNIFESP Google Scholar
Longoni Calio, M. Autor UNIFESP Google Scholar
Aparecida Santos, M. Autor UNIFESP Google Scholar
Antonio Bertoncini, C. R. Autor UNIFESP Google Scholar
Silva Sasso, G. da Autor UNIFESP Google Scholar
Santos Simoes, R. Google Scholar
Jesus Simoes, M. Autor UNIFESP Google Scholar
Soares, J. M. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Objective We evaluated whether genistein or estrogen treatment has the same effect when administered immediately or late to rats induced with menopause using ovariectomy.Methods Sixty adult female rats were divided into six treatment groups: GI = vehicle immediately after ovariectomy; GII = vehicle 30 days after ovariectomy; GIII = genistein immediately after ovariectomy; GIV = genistein 30 days after ovariectomy; GV = estrogen immediately after ovariectomy; and GVI = estrogen 30 days after ovariectomy. All animals were treated for 30 consecutive days. At the end of the treatment, part of the uteri was removed for subsequent histological studies and another part was used to evaluate estrogen receptors 1 and 2, cell proliferation (cyclin A1 and A2, cyclin D1, cyclin-dependent kinase inhibitors 1, 1B and 2, antigen identified by the monoclonal antibody Ki67) and angiogenesis (vascular endothelial growth factor, VEGF-A) gene expression.Results Late treatment after castration in rats resulted in more developed endometrium, enhanced cell proliferation and estrogen-signalling pathways, particularly the cyclin-related genes Ki67 and VEGF-A, compared to early treatment. Interestingly, these same effects were less intense with genistein compared to those induced by estrogen, especially when genistein was administered late.Conclusion Our data show that isoflavone renders a lower risk of cancer when compared to estrogen in treatments.
Keywords 17 beta-ESTRADIOL
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2015-06-01
Published in Climacteric. London: Informa Healthcare, v. 18, n. 3, p. 389-398, 2015.
ISSN 1369-7137 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 389-398
Access rights Closed access
Type Article
Web of Science ID WOS:000354403800014

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