Essential oil from the leaves of Xylopia langsdorfiana (Annonaceae) as a possible spasmolytic agent

Essential oil from the leaves of Xylopia langsdorfiana (Annonaceae) as a possible spasmolytic agent

Author Correia, Ana Carolina de C. Google Scholar
Ferreira, Tamyris F. Google Scholar
Martins, Italo Rossi R. Google Scholar
Macedo, Ciberio L. Google Scholar
Monteiro, Fabio de S. Google Scholar
Costa, Vicente Carlos O. Google Scholar
Tavares, Josean F. Google Scholar
Silva, Marcelo S. Google Scholar
Paredes-Gamero, Edgar J. Autor UNIFESP Google Scholar
Buri, Marcus V. Autor UNIFESP Google Scholar
Rigoni, Vera L. S. Autor UNIFESP Google Scholar
Nouailhetas, Viviane L. A. Autor UNIFESP Google Scholar
Da Silva, Bagnolia A. Google Scholar
Institution Universidade Federal da Paraíba (UFPB)
Universidade Federal de São Paulo (UNIFESP)
Abstract Xylopia langsdorfiana A. St.-Hil. &Tul. (Annonaceae) is popularly known in the northeast of Brazil as pimenteira da terra', and an essential oil (XL-OE) was extracted from its leaves. Since Xylopia species are cited in folk medicine and diterpenes from X. langsdorfiana have spasmolytic activity, this study aimed to investigate a possible spasmolytic action of XL-OE on smooth muscle models. XL-OE (243 and 729g/mL) showed low pharmacologic efficacy on guinea pig trachea and rat aorta and uterus. However, in guinea pig ileum, XL-OE (27-729g/mL) inhibited carbachol or histamine-induced phasic contractions (1M) in a significant and concentration-dependent manner. in addition, XL-OE (81g/mL) reduced fluorescence intensity in ileal myocytes stimulated by histamine, indicating a decrease in cytosolic calcium concentration, which could explain the spasmolytic activity. Thus, XL-OE proved to be a promising natural product to be used in gastrointestinal diseases acting by modulating the cytosolic calcium concentration.
Keywords Annonaceae
smooth muscle
antispasmodic
calcium
essential oil
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2015-05-19
Published in Natural Product Research. Abingdon: Taylor & Francis Ltd, v. 29, n. 10, p. 980-984, 2015.
ISSN 1478-6419 (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis Ltd
Extent 980-984
Origin http://dx.doi.org/10.1080/14786419.2014.964706
Access rights Closed access
Type Article
Web of Science ID WOS:000353422200017
URI http://repositorio.unifesp.br/handle/11600/39109

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